PTPRF Antibody, Biotin conjugated

說明書

中文名稱：

PTPRF兔多克隆抗體, Biotin偶聯(lián)
貨號：

CSB-PA019053LD01HU
規(guī)格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PTPRF Polyclonal antibody
Uniprot No.：

P10586
基因名：

PTPRF
別名：

FLJ43335 antibody; FLJ45062 antibody; FLJ45567 antibody; LAR antibody; LAR protein antibody; LARFN5C antibody; LARS antibody; LCA homolog antibody; Leukocyte antigen related (LAR) PTP receptor antibody; Leukocyte antigen related antibody; Leukocyte antigen related PTP receptor antibody; Leukocyte antigen related tyrosine phosphatase antibody; Leukocyte common antigen related antibody; Protein Tyrosine Phosphatase Receptor Type F antibody; Protein tyrosine phosphatase receptor type F polypeptide antibody; Ptprf antibody; PTPRF protein antibody; PTPRF_HUMAN antibody; Receptor linked protein tyrosine phosphatase LAR antibody; Receptor type tyrosine protein phosphatase F antibody; Receptor type tyrosine protein phosphatase F precursor antibody; Receptor-type tyrosine-protein phosphatase F antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Receptor-type tyrosine-protein phosphatase F protein (688-970AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.; The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
基因功能參考文獻：
1. transferred nuclear Overhauser effects (trNOEs) have been employed in the docking program HADDOCK to generate models for the LAR-fondaparinux complex. These models are further analyzed by postprocessing energetic analysis to identify key binding interactions. PMID: 29570275
2. PTPRF may have value as a predictive marker to identify which patients can obtain the greatest benefit from erlotinib in the post-first-line setting. PMID: 26291013
3. Homozygous truncating PTPRF mutation causes athelia. PMID: 24781087
4. PTPRF is down-regulated in hepatocellular carcinoma-facilitated tumor development. PMID: 24470239
5. Interaction between the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses. PMID: 23986473
6. LAR functions as a negative regulator of adipogenesis. PMID: 19910497
7. regulation of expression by cell density through functional E-cadherin complexes PMID: 12095414
8. LAR PTPase domains play distinct functional roles in phosphorylation and dephosphorylation PMID: 12496362
9. LAR as a crucial regulator of the sensitivity of two key insulin signalling pathways to insulin PMID: 15896785
10. Results identify a protein tyrosine phosphatase as a potential substrate of TACE and describe proteolytic processing of PTP-LAR as a means of regulating phosphatase activity downstream and thus under the control of EGFR-mediated signaling pathways. PMID: 16478662
11. Regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII. PMID: 17419996
12. LAR and Src are identified as Death-associated protein kinase (DAPK) regulators through their reciprocal modification of DAPK Y491/492 residues and establishes a functional link of this DAPK-regulatory circuit to tumor progression. PMID: 17803936
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相關疾病：

Aplasia or hypoplasia of the breasts and/or nipples 2 (BNAH2)
亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Protein-tyrosine phosphatase family, Receptor class 2A subfamily
數(shù)據庫鏈接：

HGNC: 9670

OMIM: 179590

KEGG: hsa:5792

STRING: 9606.ENSP00000353030

UniGene: Hs.272062

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