PTGDS Antibody, FITC conjugated
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中文名稱：PTGDS兔多克隆抗體, FITC偶聯
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貨號：CSB-PA018969HC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PTGDS Polyclonal antibody
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Uniprot No.：
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基因名：PTGDS
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別名：Beta trace protein antibody; Beta-trace protein antibody; Cerebrin 28 antibody; Cerebrin-28 antibody; glutathione independent PGD synthase antibody; Glutathione independent PGD synthetase antibody; Glutathione-independent PGD synthase antibody; L PGDS antibody; Lipocalin type prostaglandin D synthase antibody; Lipocalin-type prostaglandin-D synthase antibody; LPGDS antibody; PDS antibody; PGD2 antibody; PGD2 synthase antibody; PGDS antibody; PGDS2 antibody; prostaglandin D synthase antibody; prostaglandin D2 synthase (21 kDa; brain) antibody; prostaglandin D2 synthase (brain) antibody; prostaglandin D2 synthase 21kDa (brain) antibody; Prostaglandin D2 synthase antibody; prostaglandin H2 D isomerase antibody; Prostaglandin-D2 synthase antibody; Prostaglandin-H2 D-isomerase antibody; PTGDS antibody; PTGDS_HUMAN antibody; RP23-47P18.11-006 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Prostaglandin-H2 D-isomerase protein (23-190AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR.
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基因功能參考文獻：
- High lipocalin-type prostaglandin D synthase expression is associated with Spontaneous intracranial hypotension. PMID: 29621631
- Measurement of serum BTP can be a reliable tool for detecting kidney function in neonates. PMID: 29421771
- Thus, our results suggest decreased NK cell-mediated eosinophil regulation, possibly through an increased level of PGD2, as a previously unrecognized link between PG dysregulation and eosinophilic inflammation in CRS. PMID: 27271931
- These observations suggest that tumor cell-derived inflammatory cytokines increase L-PGDS expression and subsequent PGD2 production in the tumor endothelial cells (ECs). This PGD2 acts as a negative regulator of the tumorigenic changes in tumor ECs. PMID: 29124765
- The cut off value for betaTP in the diagnosis and follow-up of cerebrospinal fluid leaks should be modified depending on the type of secretion (sample type), for a better diagnostic accuracy PMID: 27614217
- Serum levels of beta trace protein and beta 2 microglobulin can be used to predict residual kidney function in hemodialysis patients. PMID: 26924065
- BTP and B2M levels are less affected than serum by amputation, and should be considered for future study of GFR estimation PMID: 26800100
- Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human T(H)2 cell subpopulation with enhanced function PMID: 26431580
- levels of L-PGDS in cervicovaginal secretions of pregnant women at different stages of parturition correlate with preterm birth. PMID: 25964109
- Given that uPGDS levels fall after treatment of LN, uPGDS may be used to monitor the efficacy of therapy. It can also differentiate patients with active nephritis and active non renal lupus. PMID: 26211517
- PTGDS mRNA expression was down-regulated in rapid-cycling bipolar disorder patients in a euthymic, depressive, and manic/hypomanic state compared with healthy control subjects. PMID: 25522430
- Expression of MR and prostaglandin D2 synthase is strongly correlated in adipose tissues from obese patients. PMID: 25966493
- involved in pathogenesis of androgenetic alopecia [review] PMID: 24521203
- These data indicate that scalp is spatially programmed via mast cell prostaglandin D-synthase distribution in a manner reminiscent of the pattern seen in androgenetic alopecia. PMID: 24438498
- These results suggest that L-PGDS acted as a scavenger of biliverdin, which is a molecule not found in normal CSF. PMID: 25005874
- Among NSTE-ACS patients, BTP and CysC were superior to conventional renal parameters for predicting MB, and improved clinical stratification for hemorrhagic risk. PMID: 23698027
- Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase. PMID: 23526831
- betaTP, beta2M, CysC, and creatinine differ in their associations with demographic and clinical factors, suggesting variation in their non-glomerular filtration rate determinants. PMID: 23335043
- All-cause and cardiovascular mortality are strongly associated with beta-trace protein marker levels and beta-microglobulin in a representative sample of US adults. PMID: 23518194
- The results we obtained from mice led to our investigation of PTGDS in 29 human cryptorchid patients but we failed to find any mutation that supported an involvement of this gene in human testicular descent. PMID: 23076868
- no overall evidence of an association between wireless phone use and serum concentrations of beta-trace protein PMID: 22989106
- Elevated plasma level of beta-trace protein associated with all cause of death in patients with acute coronary syndrome. PMID: 22818840
- The serum level of beta-trace protein is an independent predictor of death and cardiovascular disease mortality in incident hemodialysis patients. PMID: 22745274
- Low PTGDS expression is associated with testis cancer. PMID: 22960220
- L-PGDS expression may contribute to the restricted proliferation of epidermal melanocytes, but conversely its overexpression may reflect the dysregulated proliferation of melanoma cells. PMID: 22299829
- The gene coding for PTGDS was found to be more expressed in patients with attention deficit hyperactivity disorder (ADHD)relative to patients with bipolar disorder indicating a possible link with the differential etiology of ADHD. PMID: 22370065
- Data suggest that L-PGDS binds small lipophilic ligands with both high-affinity and low-affinity interactions; molecular models are proposed from studies that include binding of hemin, biliverdin, and bilirubin. PMID: 22677050
- Ascites and pleural effusion contain high concentrations of beta-TP that exceed the levels in corresponding plasma PMID: 21501068
- Urinary PGDS, not ZA2G, may serve as a biomarker for active LN and upon validation in larger studies, may become the non-invasive test to evaluate the disease activity in future management of LN. PMID: 22498882
- NM 000954 NM 000954 PMID: 22342541
- these results demonstrate that L-PGDS protected against neuronal cell death by scavenging reactive oxygen species without losing its ligand-binding function PMID: 22248185
- Beta-trace protein can be used as an alternative diagnostic tool to detect moderate or severe glomerular filtrate rate reduction in patients after liver transplantation. PMID: 21745310
- two genes involved in cardiovascular diseases, ADORA1 and PTGDS, were differentially up-regulated in epicardial adipose tissue compared to mediastinal and subcutaneous adipose tissue PMID: 21603615
- Lipocalin-type prostaglandin D synthase is associated with coronary vasospasm and vasomotor reactivity in response to acetylcholine PMID: 21325722
- Proteomic profiling of cerebrospinal fluid identifies prostaglandin D2 synthase as a putative biomarker for pediatric medulloblastoma. PMID: 21271676
- RBP-4, lipocalin-2 and L-PGDS do not regulate insulin sensitivity in healthy men. Rather their expression seemed to reflect inflammatory activity and were inversely correlated with alcohol intake and serum HDL levels. PMID: 21104585
- Report the presence of L-PGDS in the COX-2-expressing cells in the mucosa of active ulcerative colitis patients in parallel with disease activity. PMID: 21163901
- It may be feasible to test for perilymphatic fluid fistula using PTGDS in samples from the tympanic cavity. PMID: 21192373
- Met64 seems to function as a kinetic clamp, pushing the thiol group of Cys65 close to the site of nucleophilic attack during catalysis. PMID: 20667974
- Using RT-PCR we demonstrated that L-PGDS gene expression decreased proportionately with tumor progression in lung cancer. PMID: 20144489
- L-PGDS may fine-tune the retinoic acid signalling in melanocytes. PMID: 20403807
- This study included 62 persons aged 18-30 years and cell phone exposure. EMF emissions may down-regulate the synthesis of beta-trace protein. PMID: 20596612
- protein levels in nasal fluids can serve for diagnosis of cerebrospinal fluid leak PMID: 19958607
- This beta-trace protein based formula was found to estimate GFR with reasonable precision PMID: 19949816
- The expression of H-PGDS in human dendritic cells (DCs) and the regulatory mechanisms by which DCs produce prostaglandin D2, is demonstrated. PMID: 20008150
- As the CSF is in contact with axons and mitochondria of the optic nerve, we postulate that a change in the concentration of CSF protein such as L-PGDS could exercise a harmful effect on these structures. PMID: 19598000
- Pronounced eosinophilia and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice PMID: 11751991
- Study performed in patients with kidney function ranging from normal to advanced renal failure suggests that serum beta-trace protein is an indicator of impaired glomerular filtration rate. PMID: 12900000
- The circadian lipocalin-type PGDS pattern and its suppression by total sleep deprivation indicate an interaction of the prostaglandin D system and human sleep regulation. PMID: 15453544
- Shear stress induces l-PGDS expression by transcriptional activation through the AP-1 binding site. PMID: 15718494
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亞細胞定位：Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm, perinuclear region. Secreted. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.
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蛋白家族：Calycin superfamily, Lipocalin family
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組織特異性：Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, epididymis and prosta
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