PTBP2 Antibody, Biotin conjugated
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中文名稱：PTBP2兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA892133LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PTBP2 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：brPTB antibody; FLJ34897 antibody; MIBP antibody; Neural polypyrimidine tract binding protein antibody; Neural polypyrimidine tract-binding protein antibody; Neurally enriched homolog of PTB antibody; Neurally-enriched homolog of PTB antibody; nPTB 5 antibody; nPTB 6 antibody; nPTB 7 antibody; nPTB 8 antibody; nPTB antibody; nPTB5 antibody; nPTB6 antibody; nPTB7 antibody; nPTB8 antibody; Polypyrimidine tract binding protein 2 antibody; Polypyrimidine tract-binding protein 2 antibody; PTB antibody; PTB like antibody; PTB like protein antibody; PTB-like protein antibody; PTBLP antibody; PTBP 2 antibody; Ptbp2 antibody; PTBP2_HUMAN antibody; Splicing regulator antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Polypyrimidine tract-binding protein 2 protein (13-289AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation.; Reduced affinity for RNA.
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基因功能參考文獻：
- It has been established that PTBP1 and PTBP2 are members of a family of cryptic exon repressors. PMID: 27681424
- PTBP1 and PTBP2 impaired autoregulation of SRSF3 in oral squamous cell carcinoma cancer cells. PMID: 26416554
- Data show that polypyrimidine tract-binding proteins nPTB and ROD1 interact with mitochondrial tRNA(Thr) in the cytoplasm outside of mitochondria. PMID: 26657638
- In T98G glioma cells, the level of sumoylated PTBP2 was reduced compared to that of normal brain cells. Overall, this study shows that PTBP2 is posttranslationally modified by SUMO1. PMID: 24286314
- MALAT1 binds to SFPQ releasing PTBP2 from the SFPQ/PTBP2 complex, the increased SFPQ-detached PTBP2 promotes cell proliferation and migration in colorectal cancer. PMID: 25025966
- Defining the multifunctional roles of PTB will contribute to the understanding of key regulatory events in gene expression. PMID: 24264039
- Changes in miR-223/PTBP2 pathway could contribute of abnormal splicing in chronic myeloid leukemia. PMID: 23174904
- Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 calcium channel transcript by polypyrimidine tract-binding protein. PMID: 21282112
- present fluorescence, NMR, and in vivo splicing data in support of a role of PTB in inducing RNA loops. We show that the RNA recognition motifs (RRMs) 3 and 4 of PTB can bind two distant pyrimidine tracts and bring their 5' and 3' ends in close proximity PMID: 20160105
- The nPTB proximal promoter, although rich in G+C content and presenting putative binding sites for the transcription factors Sp1, NF-1, NF-kB and Oct-1, lacks a typical TATA box. PMID: 16002244
- Study shows that PTB can function as an anti-repressor molecule to counteract the splicing inhibitory activity of SRp30c. PMID: 17548433
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亞細胞定位：Nucleus.
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組織特異性：Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform
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數據庫鏈接：
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