PSMD4 Antibody
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中文名稱：PSMD4兔多克隆抗體
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貨號(hào)：CSB-PA018908HA01HU
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規(guī)格：￥440
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圖片：
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Western Blot
Positive WB detected in: HepG2 whole cell lysate, 293T whole cell lysate
All lanes: PSMD4 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 41, 29 kDa
Observed band size: 41 kDa -
IHC image of CSB-PA018908HA01HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. -
IHC image of CSB-PA018908HA01HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) PSMD4 Polyclonal antibody
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Uniprot No.：
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基因名：PSMD4
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別名：26S protease subunit S5a antibody; 26S proteasome non ATPase regulatory subunit 4 antibody; 26S proteasome non-ATPase regulatory subunit 4 antibody; 26S proteasome regulatory subunit rpn10 antibody; 26S proteasome regulatory subunit S5A antibody; AF 1 antibody; AF antibody; AF1 antibody; Angiocidin antibody; Antisecretory factor 1 antibody; ASF antibody; DS5a antibody; MCB 1 antibody; MCB1 antibody; Multiubiquitin chain binding protein antibody; Multiubiquitin chain-binding protein antibody; OTTHUMP00000059963 antibody; Prosome macropain antibody; Proteasome (prosome macropain) 26S subunit non ATPase 4 antibody; Proteasome 19S S5A antibody; Proteasome 26S non ATPase subunit 4 antibody; Proteasome 26S subunit non ATPase 4 antibody; PSMD 4 antibody; Psmd4 antibody; PSMD4_HUMAN antibody; pUB R5 antibody; pUBR5 antibody; Rpn 10 antibody; Rpn10 antibody; RPN10 homolog antibody; S5A antibody; S5a/antisecretory factor protein antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human 26S proteasome non-ATPase regulatory subunit 4 protein (161-377AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
本頁(yè)面中的產(chǎn)品，PSMD4 Antibody (CSB-PA018908HA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于PSMD4 Antibody，我們還提供其他標(biāo)記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains.
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基因功能參考文獻(xiàn)：
- Preterm delivery is associated with low levels of anti-secretory factor in placenta. Inflammation, a potential trigger of preterm birth, is more pronounced in the preterm placenta and inversely related to the placental level of anti-secretory factor. PMID: 29265188
- We therefore suggest that PSMD4 or b-catenin might be potential targets for suppressing tumor aggressiveness, and consequently, improving outcomes in patients whose tumors express cNrf2. PMID: 27033953
- Binding (especially high-affinity binding) of non-ubiquitinated proteins to the Rpn10 proteasome subunit can both regulate the functioning of this proteasomal ubiquitin receptor (by competing with ubiquitinated substrates) and promote activation of other pathways for proteolytic degradation of proteins destined to the proteasome. PMID: 28988533
- The platelet 26S proteasome exhibits different basal activities of its catalytic subunits and chymotrypsin-like activity is most prominently enhanced by calcium dependent signaling. Collagen stimulation enhances 26S proteasome chymotrypsin-like activity in platelets. PMID: 27768934
- regulation of NY-ESO-1 processing by the ubiquitin receptors Rpn10 and Rpn13 as a well as by the standard and immunoproteasome is governed by non-canonical ubiquitination on non-lysine sites. PMID: 26903513
- Not only AF1, but an entire proteasome complex, seems to be present in blood. PMID: 25897558
- binds to death receptor-6, and induces monocyte cell line differentiation via NF-kB pathway PMID: 24829148
- The VWA domain regulation of ubiquitin and Ubl binding to S5a is restricted to the 26S proteasome. PMID: 25318673
- The degradation of TP53 and MDM2 by the proteasome can be selectively dependent on S5a in human cells. PMID: 24121268
- To examine angiocidin expression in SMMC-7221 and HepG2 cells and the role of angiocidin in liver cancer cell growth. Angiocidin is highly expressed in liver cancer cells, and it may play a key role in tumor growth of liver cancers. PMID: 24250289
- Authors demonstrate that human cytomegalovirus UL76 induces a novel nuclear aggresome, likely by subverting S5a of the ubiquitin-proteasome system. PMID: 23966401
- One consequence of the interaction between E6/E6AP and S5a is enhanced ubiquitination of this proteasome subunit. PMID: 24074603
- These studies suggest that diminished 26S activity in failing human hearts may be related ti impaired docking of the 19S to the 20S as a result of decreased Rpt subunit ATPase activity and alpha7 subunit phosphorylation. PMID: 23515276
- identified the VWA domain of hRpn10 as a receptor for ubiquitin-like proteins within the 26S proteasome and elucidated how FAT10 mediates efficient proteolysis by the proteasome PMID: 22434192
- Both higher PSMD4 expression levels and higher 1q21 copy numbers affected clinical outcome adversely. PMID: 21628408
- results suggest that there is different substrate specificity between S5a and hRpn13 at the level of delivery and S5a may be the major docking site for ERAD substrates. PMID: 20417181
- Overexpression of the S5a subunit of proteasome activator PA700 did not recover proteasome function in Huntington disease cells. S5a. PMID: 17327906
- parkin Ubld uses differential surfaces to recruit UIM regions from the S5a proteasomal subunit compared with Eps15 involved in cell signaling. PMID: 19875440
- S5a component of the 19S complex interacts with different ubiquitin-like (ubl) modules PMID: 11827521
- HHr23a binds to this protein, which changes its own conformation. PMID: 14557549
- structure of the ubiquitin-interacting motif of the proteasome subunit S5a bound to the ubiquitin-like domain of HR23B PMID: 14585839
- Results report the structure of S5a (196-306) alone and complexed with two monoubiquitin molecules, and present a model for how S5a and other ubiquitin-binding proteins recognize polyubiquitin. PMID: 15826667
- These results are consistent with the conclusion that the anti-tumor activity of angiocidin arises from its ability to ligate collagen and alpha2beta1 on endothelial cells and tumor cells. PMID: 16762342
- UIM2 domain of S5a binds preferentially to hHR23a over polyubiquitin, and a model is provided for the ternary complex that represents one of the mechanisms used by the proteasome to capture ubiquitylated substrates. PMID: 17408689
- results suggest that S5a is regulated during apoptosis at the transcriptional level and S5a upregulation by antiapoptotic signals can contribute to cell survival. PMID: 17459097
- S5a-UIMs can be used as upstream inhibitors of the proteasome pathway. PMID: 17949686
- In autoimmune disorders like MS, angiocidin activates T cells, macrophages, microglia & astrocytes to produce inflammatory cytokines and to stimulate antigen presentation. PMID: 18207252
- angiocidin activates monocytes to secrete cytokines and differentiates them to a macrophage-like phenotype through at least two pathways mediated by MAPK and NF-kappaB, as well as PI3K PMID: 18632645
- The presence of S5a in the reaction containing a substrate (luciferase), ubiquitination enzymes (an E2, UbcH5, and the U-box E3 ligase CHIP) and 26S proteasome significantly increased the rate of luciferase degradation. PMID: 19387488
- Angiocidin's ability to elicit tumor cell death may be mediated in part by it's pro-inflammatory effects on immune cells in the tumor microenvironment. PMID: 19519434
- The binding of S5a to K48-linked diubiquitin is defined at an atomic level resolution. PMID: 19683493
- Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 (also called subunit 5a) has two independent polyubiquitin binding sites whose sequences are highly conserved among higher eukaryotic orthologs. PMID: 9488668
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蛋白家族：Proteasome subunit S5A family
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