PSMB9 Antibody, FITC conjugated

說明書

中文名稱：

PSMB9兔多克隆抗體, FITC偶聯
貨號：

CSB-PA018887LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PSMB9 Polyclonal antibody
Uniprot No.：

P28065
基因名：

PSMB9
別名：

Beta1i antibody; Large multifunctional peptidase 2 antibody; Large multifunctional protease 2 antibody; LMP 2 antibody; LMP2 antibody; Low molecular mass protein 2 antibody; Macropain chain 7 antibody; MGC70470 antibody; Multicatalytic endopeptidase complex chain 7 antibody; OTTHUMP00000062982 antibody; Proteasome (prosome macropain) subunit beta type 9 antibody; proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) antibody; Proteasome beta 9 subunit antibody; Proteasome catalytic subunit 1i antibody; Proteasome chain 7 antibody; Proteasome related gene 2 antibody; Proteasome subunit beta 6i antibody; Proteasome subunit beta type 9 antibody; Proteasome subunit beta type-9 antibody; Proteasome subunit beta-1i antibody; PSB9_HUMAN antibody; PSMB 9 antibody; PSMB6i antibody; PSMB9 antibody; Really interesting new gene 12 protein antibody; RING 12 antibody; RING12 antibody; RING12 protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Proteasome subunit beta type-9 protein (21-219AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
基因功能參考文獻：
1. Defective PSMB9/beta1i expression is likely to be one of the risk factors for the development of human uterine neoplasm. PMID: 28482675
2. single nucleotide polymorphism in PSMB9 are associated with hand dermatitis PMID: 27258892
3. Chinese females carrying the rs17587-G/G genotype in PSMB9 may increase a higher risk for Parkinson's disease. PMID: 27098790
4. The TAP1-rs1135216 and PSMB9-rs17587 variants are significantly associated with vitiligo, and even one copy of these mutant alleles can influence the risk among Saudis. PMID: 25548428
5. study found prevalence of LMP2-AA genotype was higher in acute myeolid leukemia (AML) patients while it was significantly lower in multiple myeloma (MM) cases than in the control subjects; results suggestLMP2 polymorphisms could play a role in the development of AML and MM PMID: 24377540
6. Data indicate that the codon 60 Arg/His polymorphism does not significantly alter the expression and activity of beta1i among the cell lines tested and clinical samples from colon and pancreatic cancer. PMID: 24040045
7. functional variants in PSMB9 may contribute to melanoma susceptibility. PMID: 23360169
8. LMP2 has a role as a tumor-suppressor and may have a role in uterine leiomyosarcoma therapy PMID: 22355695
9. Genetic polymorphisms of rs17587 of PSMB9 appeared to be associated with rheumatoid arthritis in ethnic Han Chinese from Yunnan. PMID: 23568741
10. study reports expression of LMP2 in patients with renal oncocytomas (RO) and eosinophilic variant of chromophobe renal cell carcinomas (CHRCC-EO); all CHRCC-EO cases (7 of 7) strongly showed nuclear LMP2 staining, as opposed to only 2 of 56 ROs; suggest its use as an aid in differential diagnosis of these neoplasias PMID: 22705098
11. LMP2 expression in nasopharyngeal carcinoma is associated with poor prognosis. PMID: 22287277
12. The polymorphic site is unique in the Chinese population of Han nationality at the LMP2 codon 60 loci (Arg60Cys), but a lack of association with lung cancer exists. PMID: 22261389
13. LMP2 may negatively regulate LMS independently of its role in the proteasome. PMID: 22659265
14. This is the first study to demonstrate that LMP2 variants can affect radiographic severity in ankylosing spondylitis. PMID: 22034108
15. Data show that LMP2 60HH variant reduces the risk to develop MS amongst Italian HLA-A*02+ females. PMID: 20174631
16. downregulation of expression in PBMC of chronic hepatitis B patients PMID: 20300807
17. data show that the proteasomal ss1i subunit is dysregulated in peripheral white blood cells and in inflammatory infiltrates of minor salivary glands in patients with Sjogren's syndrome PMID: 19833746
18. a high-frequency TAP1/LMP2 promoter polymorphism in human tumors PMID: 11788900
19. caspase inhibition led to elevated levels of LMP2 and oxidized proteins; results suggest an age-related loss in capacity to carry out apoptosis might contribute to the observed accumulation of oxidized proteins during aging and in age-related diseases. PMID: 15284441
20. These data suggest that LMP2 contributes to IkappaBalpha degradation and p50 generation, and that inhibition of LMP2 suppresses expression and activities of MMP-2 and MMP-9 by blocking the transfer of active NF-kappaB heterodimers into the nucleus. PMID: 16222703
21. LMP2-associated proteasome is recruited to the entire sequence of ER target genes, implicating a role for the proteasome in both transcription initiation and elongation. PMID: 16957778
22. These data reveal a novel "feed-forward" mechanism induced by NF-kappaB which ensures that acutely synthesized IRF-1 operates in concert with NF-kappaB to amplify the immunoproteasome and antigen-processing functions of CD40. PMID: 18694960
23. Downregulation of LMP2 is associated with acute myeloid leukaemic blasts. PMID: 19148137
24. Obtained data suggest the LMP2 and PSMA6 gene polymorphism significance as the risk factors of essential hypertension in adolescents. PMID: 19526842
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

Peptidase T1B family
數據庫鏈接：

HGNC: 9546

OMIM: 177045

KEGG: hsa:5698

STRING: 9606.ENSP00000363993

UniGene: Hs.654585

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