PSAT1 Antibody

中文名稱：

PSAT1兔多克隆抗體
貨號：

CSB-PA018838LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA018838LA01HU diluted at 1:200 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system.

Immunofluorescence staining of HepG2 cells with CSB-PA018838LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PSAT1 Polyclonal antibody
Uniprot No.：

Q9Y617
基因名：

PSAT1
別名：

EC 2.6.1.52 antibody; Endometrial progesterone induced protein antibody; EPIP antibody; MGC1460 antibody; NLS2 antibody; Phosphohydroxythreonine aminotransferase antibody; phosphoserine aminotransferase 1 antibody; Phosphoserine aminotransferase antibody; PSA antibody; PSAT antibody; Psat1 antibody; PSATD antibody; SERC_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Phosphoserine aminotransferase protein (104-206AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PSAT1 Antibody (CSB-PA018838LA01HU)，的標記方式是Non-conjugated。對于PSAT1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA018838LB01HU	PSAT1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA018838LC01HU	PSAT1 Antibody, FITC conjugated
Biotin	CSB-PA018838LD01HU	PSAT1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
基因功能參考文獻：
1. PSAT1 protein and mRNA levels were significantly associated to poor outcome to tamoxifen treatment of breast cancer. PMID: 28522855
2. PSAT1, which is overexpressed in ER-negative breast cancers, is activated by ATF4 and promotes cell cycle progression via regulation of the GSK3beta/beta-catenin/cyclin D1 pathway. PMID: 29216929
3. Data suggest that phosphoserine aminotransferase 1 (PSAT1) may be a promising anticancer therapeutic target. . PMID: 27372650
4. High expression of PSAT is associated with Colon Cancer. PMID: 26439504
5. PSAT1 expression positively correlates with the levels of phosphorylated cyclin D1 in non-small cell lung cancer. PMID: 25142862
6. phosphoserine aminotransferase deficiency is associated with Neu-Laxova syndrome. PMID: 25152457
7. we propose an idea that PSAT1 may be implicated in altered serine metabolism and schizophrenia spectrum conditions. PMID: 20955740
8. nucleotide sequence and enzymatic activity of two isoforms generated by alternative splicing; differential expression depending upon tissue specificity and cellular proliferation status PMID: 12633500
9. Overexpression of phosphoserine aminotransferase is associated with colorectal cancer development PMID: 18221502
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相關疾病：

Phosphoserine aminotransferase deficiency (PSATD); Neu-Laxova syndrome 2 (NLS2)
蛋白家族：

Class-V pyridoxal-phosphate-dependent aminotransferase family, SerC subfamily
組織特異性：

Expressed at high levels in the brain, liver, kidney and pancreas, and very weakly expressed in the thymus, prostate, testis and colon.
數據庫鏈接：

HGNC: 19129

OMIM: 610936

KEGG: hsa:29968

STRING: 9606.ENSP00000365773

UniGene: Hs.494261

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