PRPF40A Antibody
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中文名稱：PRPF40A兔多克隆抗體
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貨號：CSB-PA018769LA01HU
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規格：￥440
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圖片：
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Western Blot
Positive WB detected in: U251 whole cell lysate, Hela whole cell lysate, 293T whole cell lysate
All lanes: PRPF40A antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 109, 106, 107, 11 kDa
Observed band size: 109 kDa -
IHC image of CSB-PA018769LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PRPF40A Polyclonal antibody
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Uniprot No.：
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基因名：PRPF40A
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別名：Fas ligand associated factor 1 antibody; Fas ligand-associated factor 1 antibody; FBP 11 antibody; FBP11 antibody; FLAF 1 antibody; FLAF1 antibody; FNBP 3 antibody; Formin binding protein 11 antibody; Formin binding protein 3 antibody; Formin-binding protein 11 antibody; Formin-binding protein 3 antibody; HIP-10 antibody; HIP10 antibody; Huntingtin interacting protein A antibody; Huntingtin interacting protein HYPA antibody; Huntingtin yeast partner A antibody; Huntingtin-interacting protein 10 antibody; Huntingtin-interacting protein A antibody; HYPA antibody; NY REN 6 antibody; NY REN 6 antigen antibody; PR40A_HUMAN antibody; Pre mRNA processing factor 40 homolog A antibody; Pre-mRNA-processing factor 40 homolog A antibody; PRP40 pre mRNA processing factor 40 homolog A (S cerevisiae) antibody; PRP40 pre mRNA processing factor 40 homolog A (yeast) antibody; PRP40 pre mRNA processing factor 40 homolog A antibody; PRPF 40A antibody; PRPF40A antibody; Renal carcinoma antigen NY-REN-6 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Pre-mRNA-processing factor 40 homolog A protein (120-266AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，PRPF40A Antibody (CSB-PA018769LA01HU)，的標記方式是Non-conjugated。對于PRPF40A Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:200-1:500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.
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基因功能參考文獻：
- our data revealed that COL1A1, UCP2, and PRPF40A are novel players implicated in the complex network of hypoxia response in non-small cell lung cancer PMID: 28258342
- Multidisciplinary approach showed that HsPrp40Ap interacts with centrin in vitro, supporting a coupled functional role for these proteins in pre-mRNA splicing. PMID: 28636910
- Study of native domain FF3-71 from human HYPA/FBP11 and the truncated version FF3-60 with C-terminal helix being deleted by molecular dynamics simulations. PMID: 22408419
- Interaction with polyglutamine-expanded huntingtin alters cellular distribution and RNA processing of huntingtin yeast two-hybrid protein A (HYPA). PMID: 21566141
- an atomic-resolution structure of an "invisible" folding intermediate of a small protein module: the FF domain; structure reveals non-native elements preventing formation of native conformation in the carboxyl-terminal part of the protein PMID: 20829478
- Data describe the structure of an FF domain from HYPA/FBP11, which differs from those of other phosphopeptide-binding domains and represents a novel phosphopeptide-binding fold. PMID: 12381297
- Results suggest an essential role of WW/FF domain-containing factors such as FBP11 and CA150 in pre-mRNA splicing that likely occurs in concert with transcription in vivo. PMID: 15456888
- NAKAP-HypA scaffold is a potential nuclear docking site for huntingtin protein and may contribute to the nuclear accumulation of huntingtin observed in HD. PMID: 16391387
- FBP11 binding mechanism underlies the molecular pathology of severe neurological disorders, e.g., Rett syndrome and Huntington disease. PMID: 17065151
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亞細胞定位：Nucleus speckle. Nucleus matrix.
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蛋白家族：PRPF40 family
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組織特異性：Expressed in the brain cortex (at protein level). Widely expressed.
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數據庫鏈接：
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