PROC Antibody, FITC conjugated
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中文名稱：PROC兔多克隆抗體, FITC偶聯(lián)
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貨號(hào)：CSB-PA018742LC01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) PROC Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Activation peptide antibody; Anticoagulant protein C antibody; APC antibody; Autoprothrombin IIA antibody; Blood coagulation factor XIV antibody; EC 3.4.21.69 antibody; PC antibody; proC antibody; PROC_HUMAN antibody; PROC1 antibody; Protein C (inactivator of coagulation factors Va and VIIIa) antibody; THPH3 antibody; THPH4 antibody; Vitamin K dependent protein C antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Vitamin K-dependent protein C protein (288-409AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
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基因功能參考文獻(xiàn)：
- The fusion protein recapitulates the functional and structural properties of the thrombin-thrombomodulin complex, prolongs the clotting time by generating pharmacological quantities of activated protein C and effectively diagnoses protein C deficiency in human plasma. PMID: 28294177
- Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women. PMID: 29363996
- Laboratory tests and direct sequencing of PROC and SERPINC1 were conducted for the patient and his family members. Coagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreased protein C activity resulting from a small insertion mutation c.848_849insGATGT in SERPINC1 and a short deletion variant c.572_574delAGA in PROC. PMID: 28861852
- Patients with rheumatoid arthritis, polymyositis, systemic lupus erythematosus and ankylosing spondylitis showed higher serum levels of than healthy control individuals. PMID: 29303701
- Using protein C-factor VII chimera demonstrate that APC light chain amino acid residues outside the EPCR-binding site enable cytoprotective PAR1 signaling. PMID: 28834159
- We recently identified a venous thrombosis patient whose plasma level of protein C antigen is normal, but its anticoagulant activity is only 34 % of the normal level. Genetic analysis revealed that the proband and her younger brother carry a novel heterozygous mutation c.346G>A, p.Gly74Ser (G74S) in PROC. PMID: 28405673
- Developed functional protein S assays that measure both the activated protein C- and TFPI-cofactor activities of protein S in plasma, which are hardly if at all affected by the FV Leiden mutation. PMID: 28211163
- Protein C seems inversely associated with mortality in patients with advanced prostate, lung and pancreatic cancer. Further research should validate protein C as a biomarker for mortality, and explore the effects of protein C on progression of cancer. PMID: 28376316
- Genetically higher protein C was associated with a lower risk of ischaemic heart disease. PMID: 27882376
- EPCR occupancy recruits G-protein coupled receptor kinase 5, thereby inducing beta-arrestin-2 biased PAR1 signaling by both APC and thrombin. In PMID: 27561318
- A novel mutation of A309V in PROC was determined in a family of two patients with late onset protein C deficiency PMID: 28111891
- loss of the convertase furin or PC5/6 in hepatocytes results in a approximately 30% decrease in APC levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin activation. PMID: 28468828
- Both probands had hereditary protein C deficiencies, for which their parents were all carriers. PMID: 28186585
- Variants influencing circulating protein C levels in the CELSR2-PSRC1-SORT1 region may indicate a novel genetic link between lipoprotein metabolism and hemostasis. PMID: 28082259
- These findings suggest that the anti-inflammatory function of APC at therapeutic concentrations may include the inhibition of NETosis in an EPCR-, PAR3-, and Mac-1-dependent manner, providing additional mechanistic insight into the diverse functions of neutrophils and APC in disease states including sepsis. PMID: 28408624
- Collectively, these data depict a pivotal role for AMPK signaling in inhibiting ER stress responses via the activation of APC during MGO-induced cardiomyocyte apoptosis. Thus, APC may be a potential novel therapeutic target for the management of diabetic cardiovascular complications such as diabetic cardiomyopathy. PMID: 27794481
- An activation-resistant homozygous protein C R229W mutation was linked to perinatal intracranial bleeding and delayed onset of thrombosis. PMID: 27172833
- Structural and functional studies of novel heterozygous mutations in the PROC gene confirmed that the mutations were pathogenetic in two Chinese families with types I and II protein C deficiency. PMID: 27517348
- The odds ratio of developing idiopathic fatal pulmonary embolism as a variant carrier for PROC is 85.6 (95% CI, 13.0-448.9; P = 2.0 x 10- 5. PMID: 28174134
- Study detected a statistically significant positive correlation between expanded disability status scale scores and thrombomodulin levels (p<0.01) and a 10% positive correlation between expanded disability status scale scores and APC levels in multiple sclerosis patients PMID: 27456888
- Low protein C expression is associated with diabetes mellitus. PMID: 27345772
- Genetic variants in thrombomodulin and endothelial protein C receptor genes are additively associated with mortality in acute respiratory distress syndrome in European ancestry PMID: 27215212
- Protein C and TAFI are concurrently activated in a thrombomoulin-dependent manner and do not compete for the thrombin-TM complex, raising the possibility that they interact with distinct activation complexes. PMID: 26663133
- We herewith present the first case of fetal ventriculomegaly and neonatal stroke associated with heterozygous PROC mutation. PMID: 26250584
- Elevated levels of circulating microparticles can play a role in carriers of mild and severe inherited thrombophilia resulting from protein C deficiency. PMID: 26354831
- deficiency associated with venous thromboembolism in pregnancy PMID: 25586317
- ApoER2 contributes cooperatively with endothelial cell protein C receptor and protease activated receptor 1 to APC-initiated endothelial antiapoptotic and barrier protective signaling. PMID: 26800564
- Results show that free activated protein C binds to membrane EPCR in ovarian cancer cells inducing cell migration via MEK-ERK and Rho-GTPase pathways. The cancer cells become highly aggressive, and secondary nodules develop because of fibrin inhibition. PMID: 26082331
- Low levels of protein C during pregnancy were not associated with adverse pregnancy outcome. PMID: 25879167
- Report activation of protein C and down-regulation of EPCR in trophobolasts stimulated with TNF-alpha. PMID: 25667200
- levels of protein C and soluble thrombomodulin in critically ill patients with acute kidney injury PMID: 25790110
- We conclude that the Cohn process significantly influences the anticoagulant activity of PC. Compared to the antigen, PC lost greater than 80% of its anticoagulant activity, but retained its amidolytic activity, during the Cohn process. PMID: 25730025
- Data show the molecular model of the complex of activated protein C (APC) with alphaVbeta3 integrin obtained by protein-protein docking approach. PMID: 24251463
- Our findings identify PROC on 2q14 as a novel candidate for childhood asthma PMID: 25643747
- Protein C is activated during in vitro thrombolysis. PMID: 26552309
- Results provide evidence that APC selectively inhibits proliferation and the inflammatory signaling pathways of rheumatoid synovial fibroblasts. PMID: 24096826
- High avidity anti-protein C antibodies by provide marker for a severe thrombotic phenotype in antiphospholipid syndrome. PMID: 25196808
- A single measurement of protein C was able to identify severe coagulopathy early in the course of sepsis. PMID: 24410881
- Suggest that PC deficiency is an independent predictor for the progression of critical limb ischemia. PMID: 25115555
- Hereditary protein C deficiency in a family with venous thrombosis was associated with two missense mutations in the PROC gene. PMID: 25748729
- Heterozygous F139V mutations caused mild reduction of protein C function, which might be the reason for survival of compound heterozygous or homozygous protein C deficiency adults carrying these mutations. PMID: 24911457
- A novel PC mutation in a healthy subject results in type II PC deficiency as diagnosed by commercial kits. PMID: 25651845
- Dialysis patients who are carriers of the AG/GG genotypes of the PROC rs1799809 had a 1.2-fold increased 5-year all-cause mortality risk. PMID: 24816905
- The study reports effects of the prothrombin Yukuhashi mutation on thrombomodulin-protein C anticoagulant system. PMID: 25149909
- observed increased APC resistance in carriers of fibrinogen gamma gene (FGG) haplotype 2, which is associated with reduced levels of the alternatively spliced fibrinogen gamma' chain. We then studied the effects of fibrinogen and its gamma' chain on APC resistance. PMID: 24951429
- Although platelet fVa shows slightly superior resistance to aPC's effects compared to plasma fVa, neither fVa is sufficiently cleaved in simulations of acute traumatic coagulopathy or pharmacologically-delivered aPC to diminish coagulation parameters. PMID: 24921658
- The inflammation-induced activation of the protein C pathway provides negative feedback inhibition of coagulation and exerts coagulation-independent anti-inflammatory and cytoprotective effects. PMID: 24759138
- Dysfunction of protein C in Japanese and Chinese in this review is significantly associated with increased risk for venous thromboembolism. PMID: 24233386
- The PROC TAA haplotype was associated with a high protein C level and increased risk of venous thrombosis. PMID: 24158116
- Decreased APC levels in patients with type 2 diabetes may serve as a biomarker to indicate the early development of diabetic nephropathy. PMID: 24660539
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相關(guān)疾病：Thrombophilia due to protein C deficiency, autosomal dominant (THPH3); Thrombophilia due to protein C deficiency, autosomal recessive (THPH4)
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亞細(xì)胞定位：Secreted. Golgi apparatus. Endoplasmic reticulum.
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蛋白家族：Peptidase S1 family
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組織特異性：Plasma; synthesized in the liver.
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