PRMT9 Antibody, Biotin conjugated

說明書

中文名稱：

PRMT9兔多克隆抗體, Biotin偶聯(lián)
貨號(hào)：

CSB-PA764718LD01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PRMT9 Polyclonal antibody
Uniprot No.：

Q6P2P2
基因名：

PRMT9
別名：

PRMT9 antibody; PRMT10 antibody; Protein arginine N-methyltransferase 9 antibody; Protein arginine N-methyltransferase 10 antibody; EC 2.1.1.320 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Putative protein arginine N-methyltransferase 9 protein (181-453AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA.
基因功能參考文獻(xiàn)：
1. Study demonstrated that PRMT9 is an oncogene that plays an important role in hepatocellular carcinoma cells invasion and metastasis through EMT by regulating Snail expression via activation of the PI3K/Akt/GSK-3beta/Snail signaling pathway. PMID: 29603830
2. Mechanistically, miR-543 inhibited PRMT9-enhanced cell oxidative phosphorylation, while miR-543 depletion promoted PRMT9-increased HIF-1alpha instability and inhibited glycolysis in osteosarcoma (OS) cells. Clinically, miR-543 expression was negatively correlated with PRMT9 expression in OS tissues. PMID: 27911265
3. The decrease in PRMT10 was canceled by knockdown of AR or an AR antagonist. These results indicate that PRMT10 plays an important role in androgen-dependent proliferation of prostate cancer cells PMID: 25799006
4. PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145. PMID: 25737013
5. Although amino acid substitutions of residues surrounding Arg-508 had no great effect on PRMT9 recognition of SF3B2, moving the arginine residue within this sequence abolished methylation. PMID: 25979344
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亞細(xì)胞定位：

Cytoplasm.
蛋白家族：

Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family
數(shù)據(jù)庫鏈接：

HGNC: 25099

OMIM: 616125

KEGG: hsa:90826

STRING: 9606.ENSP00000314396

UniGene: Hs.591692

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