PRMT2 Antibody
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中文名稱：PRMT2兔多克隆抗體
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貨號：CSB-PA229403
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA229403(PRMT2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA229403(PRMT2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：PRMT2
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別名：ANM2_HUMAN antibody; EC 2.1.1. antibody; histone arginine N methyltransferase PRMT2 antibody; Histone-arginine N-methyltransferase PRMT2 antibody; HMT 1 antibody; HMT1 (hnRNP methyltransferase S. cerevisiae) like 1 antibody; HMT1 antibody; HMT1 hnRNP methyltransferase like 1 antibody; hnRNP methyltransferase (S. cerevisiae) like 1 antibody; hnRNP methyltransferase like 1 antibody; Hrmt1l1 antibody; MGC111373 antibody; PRMT 2 antibody; PRMT2 alpha antibody; prmt2 antibody; PRMT2 beta antibody; PRMT2 gamma antibody; PRMT2 protein antibody; PRMT2L2 antibody; Protein arginine methyltransferase 2 antibody; Protein arginine N methyltransferase 2 antibody; Protein arginine N-methyltransferase 2 antibody; Zf2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Fusion protein of Human PRMT2
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:25-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
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基因功能參考文獻：
- Results show that tamoxifen resistance in breast cancer cells is connected with the downregulation of PRMT2 and the upregulation of ER-alpha36. Moreover, PRMT2 was able to interact with ER-alpha36 directly, suppress ER-alpha36 and downstream PI3K/Akt and MAPK/ERK signaling, reversing the tamoxifen resistance of breast cancer cells. PMID: 29620287
- Low splice variant of PRMT2 expression is associated with breast cancer. PMID: 28677794
- Cobl-mediated dendritic arborization required PRMT2, complex formation with PRMT2, and PRMT2's catalytic activity PMID: 29689199
- The PRMT2 interacts with SAM68 in cells and regulates its subcellular localization via the SH3 domain of PRMT2, prompting us to investigate the potential role of PRMT2 in BCL-X alternative splicing. PMID: 28057797
- This study demonstrates the role and significant correlation between a histone methyltransferase (PRMT2)-dependent signature, RORgamma, the cell-cycle regulation, DNA repair circuits, and breast cancer survival outcomes. PMID: 24911119
- This study uncovers the molecular mechanism of PRMT2 regulating the expression of CCND1 in invasive ductal breast carcinoma. PMID: 24292672
- characterization of 3 PRMT2 splice variants (PRMT2alpha, PRMT2beta, and PRMT2gamma) from breast cancer; these variants bind to ERalpha in vitro/in vivo; overall PRMT2 expression is upregulated in breast cancer and associated w/ ERalpha positivity PMID: 22093364
- Data suggest that post-transcriptional processing mechanism as alternative polyadenylation and splicing may play a crucial role in regulating human PRMT2 gene expression. PMID: 21820040
- the SH3 domain may mediate an interaction between PRMT1 and -2 in a methylation-dependent fashion PMID: 21851090
- PRMT2 is a novel ERalpha coactivator. PMID: 12039952
- PRMT2 inhibits NF-kappa B function and promotes apoptosis. PMID: 16648481
- ligand-dependent AR conformation is essential for the recruitment and nuclear translocation of PMRT2 which acts as AR-coactivator, presumably by arginine methylation. PMID: 17587566
- Here we report methylation activity from PRMT2 and compare it with PRMT1 activity using UPLC-MS/MS (ultra-performance liquid chromatography-tandem MS), gel electrophoresis, and thin-layer chromatography PMID: 19405910
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亞細胞定位：[Isoform 1]: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus.; [Isoform PRMT2Alpha]: Nucleus. Note=Excluded from nucleolus.; [Isoform PRMT2Beta]: Cytoplasm. Nucleus. Nucleus, nucleolus.; [Isoform PRMT2Gamma]: Nucleus. Note=Excluded from nucleolus.; [Isoform PRMT2L2]: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
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蛋白家族：Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family
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組織特異性：Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord.
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數據庫鏈接：
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