PPP1R11 Antibody

中文名稱：

PPP1R11兔多克隆抗體
貨號：

CSB-PA03834A0Rb
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA03834A0Rb at dilution of 1:100
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PPP1R11 Polyclonal antibody
Uniprot No.：

O60927
基因名：

PPP1R11
別名：

PPP1R11 antibody; HCGV antibody; TCTE5 antibody; E3 ubiquitin-protein ligase PPP1R11 antibody; EC 2.3.2.27 antibody; Hemochromatosis candidate gene V protein antibody; HCG V antibody; Protein phosphatase 1 regulatory subunit 11 antibody; Protein phosphatase inhibitor 3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human E3 ubiquitin-protein ligase PPP1R11 protein (1-126AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PPP1R11 Antibody (CSB-PA03834A0Rb)，的標記方式是Non-conjugated。對于PPP1R11 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA03834B0Rb	PPP1R11 Antibody, HRP conjugated	ELISA
FITC	CSB-PA03834C0Rb	PPP1R11 Antibody, FITC conjugated
Biotin	CSB-PA03834D0Rb	PPP1R11 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.
基因功能參考文獻：
1. Lentiviral gene transfer or knockdown of PPP1R11 in mouse lungs significantly affects lung inflammation and the clearance of Staphylococcus aureus. There is a negative correlation between PPP1R11 and TLR2 levels in white blood cell samples isolated from patients with Staphylococcus aureus infections PMID: 27805901
2. a model in which I3 regulates an SDS22-mediated PP1 activation step in solution that precedes SDS22 dissociation and transfer of PP1 to kinetochores, and which is required for PP1 to efficiently antagonize Aurora B. PMID: 25298395
3. Sds22 and Inhibitor-3 form a heterotrimeric complex with PP1, both in cell lysates and after purification. A pool of PP1 is complexly controlled by both Sds22 and Inhibitor-3. PMID: 17630778
4. inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response PMID: 18450750
5. Inh3 has two domains that are required for its interaction with PP1. PMID: 18951879
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組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 9285

OMIM: 606670

KEGG: hsa:6992

STRING: 9606.ENSP00000365963

UniGene: Hs.82887

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