PPIE Antibody, HRP conjugated
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中文名稱：PPIE兔多克隆抗體, HRP偶聯
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貨號：CSB-PA890944LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PPIE Polyclonal antibody
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Uniprot No.：
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基因名：PPIE
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別名：Ab1-210 antibody; Cyclophilin 33 antibody; Cyclophilin E antibody; Cyclophilin-33 antibody; CYP 33 antibody; CYP33 antibody; EC 5.2.1.8 antibody; Peptidyl prolyl cis trans isomerase E antibody; Peptidyl-prolyl cis-trans isomerase E antibody; Peptidylprolyl isomerase E (cyclophilin E) antibody; Peptidylprolyl isomerase E antibody; PPIase E antibody; PPIE antibody; PPIE_HUMAN antibody; Rotamase E antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Peptidyl-prolyl cis-trans isomerase E protein (86-141AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity.
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基因功能參考文獻：
- CypE is a host restriction factor that inhibits the functions of nucleoprotein, as well as viral replication and transcription, by impairing the formation of the viral ribonucleoprotein complex. PMID: 21887220
- binding of H3K4me3 to PHD3 domain of MLL and binding of the CYP33 RRM domain to PHD3 are mutually inhibitory, implying that PHD3 is a molecular switch for the transition between activation and repression of target genes PMID: 20677832
- PPIase domain of CyP33 regulates the conformation of MLL1 through proline isomerization within the PHD3-Bromo linker, thereby disrupting the PHD3-Bromo interface and facilitating binding of the MLL1-PHD3 domain to the CyP33-RRM domain. PMID: 20541251
- Data provide insight into the multiple functions of Cyp33 RRM and suggest a Cyp33-dependent mechanism for regulating the transcriptional activity of MLL. PMID: 20460131
- The results show that hCyP33 binds specifically to mRNA, namely poly(A)(+)RNA, and that binding stimulates the PPIase activity of hCyP33. PMID: 18258190
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亞細胞定位：Nucleus.
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蛋白家族：Cyclophilin-type PPIase family, PPIase E subfamily
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組織特異性：Found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
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數據庫鏈接：
