POLA2 Antibody, Biotin conjugated

說明書

中文名稱：

POLA2兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA614517LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) POLA2 Polyclonal antibody
Uniprot No.：

Q14181
基因名：

POLA2
別名：

AI573378 antibody; DNA directed DNA polymerase alpha 2 antibody; DNA polymerase alpha 70 kDa subunit antibody; DNA polymerase alpha subunit B antibody; DNA polymerase alpha subunit II antibody; DNA polymerase subunit alpha B antibody; DNA polymerase subunit II antibody; DPOA2_HUMAN antibody; FLJ21662 antibody; FLJ37250 antibody; polA2 antibody; Polymerase (DNA directed) alpha 2 (70kD subunit) antibody; Polymerase (DNA directed); alpha (70kD) antibody; Polymerase (DNA directed); alpha 2 accessory subunit antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human DNA polymerase alpha subunit B protein (101-400AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively.
基因功能參考文獻：
1. STN1-POLA2 interaction provides a basis for primase-polymerase alpha stimulation by human STN1. PMID: 28934486
2. our findings showed that knockdown of POLA2 increases gemcitabine resistance in human lung cancer cells. We propose that POLA2 may play a role in gemcitabine sensitivity and can be used as a prognostic biomarker of patient outcome in NSCLC pathogenesis. PMID: 28155658
3. POLA2+1747 GG/GA may be used as a prognostic biomarker of patient outcome in NSCLC pathogenesis PMID: 25521664
4. Findings indicate that tethering of primase to the replisome by DNA polymerase alpha (pol alpha) is critical for the normal action of DNA replication forks in eukaryotic cells. PMID: 22593576
亞細胞定位：

Nucleus.
蛋白家族：

DNA polymerase alpha subunit B family
數據庫鏈接：

HGNC: 30073

KEGG: hsa:23649

STRING: 9606.ENSP00000265465

UniGene: Hs.201897

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