POL2 Antibody

^{Rare Species}

說明書

中文名稱：

POL2兔多克隆抗體
貨號：

CSB-PA018309XA01SVG
規格：

￥440
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P21951
基因名：

POL2
別名：

DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A) POL2 DUN2 YNL262W N0825
反應種屬：

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
免疫原：

Synthetic Peptide (1320-1344aa)
免疫原種屬：

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Affinity-chromatography
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalytic component of the DNA polymerase epsilon complex which participates in chromosomal DNA replication. Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork. Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication.
基因功能參考文獻：
1. To dissect the Saccharomyces cerevisiae RNA polymerase II TL at individual-residue resolution, we quantitatively phenotyped nearly all TL single variants en masse.Our structural genetics approach incorporates structural and phenotypic data for high-resolution dissection of transcription mechanisms and their evolution, and is readily applicable to other essential yeast proteins. PMID: 27898685
2. dNTP pool levels correlate with Pol epsilon mutator severity PMID: 25827226
3. Authors report the presence of a [Fe-S] cluster directly within the active polymerase domain of Pol2 (residues 1-1187). PMID: 24144619
4. Labeling of DNA polymerase epsilon catalytic subunit with the nick-containing DNA repair intermediate indicates that the DNA polymerase is involved in DNA repair in yeast PMID: 21601535
5. show that subunits of DNA polymerase epsilon (Pol epsilon) are required but that Mrc1, a polymerase epsilon-associated checkpoint protein, is opposing senescence PMID: 21321081
6. The active site location occupied by Met644 in Pol epsilon is a key determinant of DNA replication fidelity. PMID: 17452367
7. RNAPII elongation is stimulated by H2B-K123 ubiquitination independent of H3-K4 methy PMID: 17543890
8. findings reveal a pattern indicating that DNA polymerase epsilon participates in leading-strand DNA replication PMID: 17615360
9. a mutation in the 3'-5' exonuclease domain of Pol2 dramatically reduces the frequency of end joins formed with initial 3' flaps. Thus, Pol2 performs a key 3' end-processing step in NHEJ. PMID: 18437220
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亞細胞定位：

Nucleus.
蛋白家族：

DNA polymerase type-B family
數據庫鏈接：

KEGG: sce:YNL262W

STRING: 4932.YNL262W

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