PLCG1 Antibody
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中文名稱：PLCG1兔多克隆抗體
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貨號：CSB-PA003818
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規格：￥1090
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圖片：
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Western Blot analysis of HepG2 cells using PLC γ1 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：1 phosphatidyl D myo inositol 4 5 bisphosphate antibody; 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 1 antibody; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 antibody; Inositoltrisphosphohydrolase antibody; Monophosphatidylinositol phosphodiesterase antibody; NCKAP3 antibody; Phosphatidylinositol phospholipase C antibody; Phosphoinositidase C antibody; Phosphoinositide phospholipase C antibody; Phosphoinositide phospholipase C-gamma-1 antibody; Phospholipase C 148 antibody; Phospholipase C gamma 1 antibody; Phospholipase C-gamma-1 antibody; Phospholipase C-II antibody; PLC gamma 1 antibody; PLC II antibody; PLC-148 antibody; PLC-gamma-1 antibody; PLC-II antibody; PLC1 antibody; PLC148 antibody; Plcg1 antibody; PLCG1_HUMAN antibody; PLCgamma1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat,Monkey
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免疫原：Synthesized peptide derived from Human PLC γ1 around the non-phosphorylation site of Y771.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
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基因功能參考文獻：
- Data suggest that FGFR3 with mutation found in SADDAN (but not FGFR3 with mutation found in TDII) affects cytoskeleton organization in chondrocytes by inducing tyrosine hyperphosphorylation of paxillin; binding of FGFR3 to PLCG1 appears to be involved. (FGFR3 = fibroblast growth factor receptor 3; SADDAN = Severe Achondroplasia with Developmental Delay and Acanthosis Nigricans; TDII = Thanatophoric Dysplasia type II) PMID: 29242050
- PLCgamma2 plays a critical role for Ca(2+) Flux in HCECs stimulated by A. fumigatus hyphae. Syk acts upstream of PLCgamma2 in the Dectin-1 signaling pathway. PMID: 30005593
- a previously unappreciated role for PLC-gamma1 in the positive regulation of Zap-70 and T-cell receptor tyrosine phosphorylation. Conversely, PLC-gamma1 negatively regulated the phosphorylation of SLP-76-associated proteins, including previously established Lck substrate phosphorylation sites within this complex. PMID: 28644030
- Syk-induced signals in bone marrow stromal cell lines are mediated by phospholipase C gamma1 (PLCgamma1) in osteogenesis and PLCgamma2 in adipogenesis. PMID: 28786489
- PLCG1, along with ITGA4 are regulated by miR-30b in clinical samples of coronary artery cells from coronary atherosclerosis patients. PMID: 27464494
- the central biological role of the novel IL-2-R/Lck/PLCgamma/PKCtheta;/alphaPIX/Rac1/PYGM signalling pathway is directly related to the control of fundamental cellular processes such as T cell migration and proliferation. PMID: 27519475
- LAT and phospholipase C-gamma dephosphorylation by SHP-1 inhibits natural killer cell cytototoxicity PMID: 27221712
- The products of PLC-gamma activity mediate the innate immune response by regulating respiratory burst, phagocytosis, cell adhesion, and cell migration. (Review) PMID: 27707630
- 1,25(OH)2D3 indirectly modulates the differentiation of Treg/Th17 cells by a ff ;ecting the VDR/PLC-gamma1/TGF-beta1pathway. These results indicate that administration 1,25(OH)2D3 supplements may be a beneficial treatment for organ transplantation recipients. PMID: 28926770
- Results show that PLCgamma-1 activation enhanced skin cell transformation. PMID: 28574619
- These results suggest that immobilized EGF increases collective keratinocyte displacement via an increase in single-cell migration persistence resulting from altered EGFR trafficking and PLCgamma1 activation. PMID: 27025961
- High FLC gamma expression is associated with Radioresistance in Glioblastoma. PMID: 26896280
- High PLC gamma expression is associated with breast cancer. PMID: 28112359
- We show that the decrease in PI(4,5)P2 level under non-stimulated conditions inhibits PTEN activity leading to the aberrant activation of the oncoprotein Akt. As well as defining a novel mechanism of Akt phosphorylation with important therapeutic consequences, we also demonstrate that differential expression levels of FGFR2, Plc11 and Grb2 correlate with patient survival PMID: 26212011
- the PLCgamma-1 signaling plays an important role in the H1N1-induced inflammatory responses. Our study suggests that targeting the PLCgamma-1 signaling is a potential antiviral therapy against H1N1 by inhibiting both viral replication and excessive inflammation. PMID: 27310357
- These results indicate that PP1 is recruited to the extracellular calcium-dependent E-cadherin-catenin-PIP5K1a complex in the plasma membrane to activate PIP5K1a, which is required for PLC-g1 activation leading to keratinocyte differentiation. PMID: 27340655
- FGFR1 dimers forms a complex with its effector PLCgamma1. PMID: 26482290
- High PLC gamma1 expression is associated with gastric adenocarcinoma. PMID: 26811493
- Report PLCG1 genetic alterations in angiosarcomas. PMID: 26735859
- expression of PLC-gamma1 and PIKE positively correlated with the tumor differentiation of oral squamous cell carcinoma. PMID: 26464646
- In a transgenic mouse model, PLCgamma1 is the dominant signaling effector by which activation of TrkB promotes epilepsy. PMID: 26481038
- hsa-miR-665 and hsa-miR-95 were downregulated in GSRCC but upregulated in intestinal gastric adenocarcinoma, and the relatively differential expression of the miRNAs negatively controlling their target genes, GLI2 and PLCG1 PMID: 25964059
- Results provide evidence that PTPRB and PLCG1 mutations are driving events in a subset of secondary angiosarcomas. PMID: 24795022
- PLLG1 protein mutations are uncommon in cutaneous T-cell lymphomas. PMID: 25910029
- PLCgamma1 is part of the molecular mechanism. PMID: 25491205
- Recurrent presence of the PLCG1 S345F mutation is associated with nodal peripheral T-cell lymphomas. PMID: 25304611
- The degradation of zonula occludens-1 (ZO-1), and claudin-2 exhibited a great dependence on the activation of the transient receptor potential melastatin (TRPM) 2 channel, phospholipase Cgamma1 (PLCgamma1) and the protein kinase Calpha (PKCalpha) signaling cascade. PMID: 23629676
- Data from structural, genetic, and mechanistic studies on the role of PLCG1 in cell biology suggest that dysfunctional forms of PLCG1 are linked to immune disorders and cancer. [REVIEW] PMID: 25456276
- This SOCS7 knockdown-attributed effect could be due to a precise anti-PLCg-1 role. PMID: 25162020
- The activation of the gamma1 isoform of phospholipase C (PLCgamma1) is critical for pressure sensing in cerebral arteries and subsequent vasoconstriction. PMID: 24866019
- these findings indicate that the PLCgamma1-R707Q mutation causes constitutive activation of PLCgamma1 and may represent an alternative way of activation of KDR/PLCg1 signaling besides KDR activation in angiosarcomas PMID: 25252913
- Results reveal that PLCG1 is genetically altered in a significant portion of Cutaneous T-cell lymphomas. PMID: 24706664
- A portion of PLC-gamma1 phosphorylated on tyrosine 783 is not found at LAT-containing clusters but instead is located at TCR-containing clusters. PMID: 24412752
- Extracellular K(+) concentration regulated the levels of activated PLC-gamma1, chromosome X, and carbachol-stimulated intracellular Ca(2+) mobilization in human endothelial cells PMID: 24785188
- Increased proliferative and survival mechanisms in cutaneous T-cell lymphoma may partially depend on the acquisition of somatic mutations in PLCG1 and other genes that are essential for normal T-cell differentiation. PMID: 24497536
- PLCG1, a signal transducer of tyrosine kinases, encoded a recurrent, likely activating p.Arg707Gln missense variant in 3 of 34 cases of angiosarcoma. PMID: 24633157
- Phospholipase C gamma1 plays a key role in cell migration and invasion. [review] PMID: 23925006
- PLCgamma1 signaling is the dominant pathway in promoting limbic epileptogenesis. PMID: 24502564
- Metastatic outcome can be dictated by the constitutive competition between Grb2 and Plcgamma1 for the phosphorylation-independent binding site on FGFR2. PMID: 24440983
- study showed that PLC-gamma directly binds c-Src through its SH2 domains, and this interaction is necessary for carbachol mediated inhibition of NHE3 activity in Caco-2/BBe/NHE3 cells PMID: 23703528
- PLC-gamma1 is highly expressed in brain and participates in neuronal cell functions mediated by neurotrophins. (Review) PMID: 23063587
- High expression of PLCgamma1, and of its activated forms, is associated with a worse clinical outcome. PMID: 22847294
- The role of four domains of human PLCG1 defined by structural and biochemical investigation. PMID: 23063561
- Data indicate that Akt expression was up-regulated with high glucose and insulin in both cell lines, whereas PLCgamma expression was enhanced in colon cancer cells only. PMID: 22554284
- analysis of two distinct mechanisms by which phospholipase C-gamma1 mediates epidermal growth factor-induced keratinocyte migration and proliferation PMID: 22749651
- T cell receptor (TCR)-mediated proliferation is impaired in PLCgamma1/PLCgamma2 double-deficient T cells compared with PLCgamma1 single-deficient T cells. PMID: 22837484
- The oncogenic truncation of this region elicits conformational changes that interfere with the Vav1-mediated activation of PLCgamma1 and that inhibit calcium mobilization. PMID: 22474331
- Report the interplay of HER2/HER3/PI3K and EGFR/HER2/PLC-gamma1 signalling in breast cancer cell migration and dissemination. PMID: 22262199
- Translocation of PLC-gamma 1 to the cell membrane and the associated calcium signal were enhanced only in mast cells responding to EP3 prostaglandin E2 receptor agonist sulprostone. PMID: 21798286
- our approach, which is applicable to any set of interval scale traits that is heritable and exhibits evidence of phenotypic clustering, identified three new loci in or near APOC1, BRAP, and PLCG1, which were associated with multiple phenotype domains. PMID: 22022282
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亞細胞定位：Cell projection, lamellipodium. Cell projection, ruffle.
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