PLA2G4C Antibody
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中文名稱：PLA2G4C兔多克隆抗體
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貨號：CSB-PA930276
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規格：￥2024
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圖片：
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Western blot analysis of extracts from Jurkat cells, using PLA2G4C antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PLA2G4C Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from internal of Human PLA2G4C.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling with implications in endoplasmic reticulum membrane homeostasis and lipid droplet biogenesis. Preferentially hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles. Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at sn-1 position of lysophospholipids. Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency. In response to dietary fatty acids, may play a role in the formation of nascent lipid droplets from the endoplasmic reticulum likely by regulating the phospholipid composition of these organelles.; (Microbial infection) May play a role in replication and assembly of human hepatitis C virus (HCV). In response to HCV infection, promotes remodeling of host endoplasmic reticulum membranes to form organelle-like structures called membranous web, where HCV replication occur. Can further mediate translocation of replication complexes to lipid droplets to enable virion assembly.; (Microbial infection) May facilitate human T-lymphotropic virus type 1 (HTLV-1) infection by promoting leukotriene B4 (LTB4) biosynthesis. LTB4 acts as a chemoattractant for HTLV-1-infected CD4-positive T cells and favors cell to cell viral transmission.
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基因功能參考文獻：
- Five single-nucleotide polymorphisms (SNPs) (rs9226, rs1045376, rs251684, rs2307279, and rs156631) in PLA2G4C and four SNPs (rs6533451, rs2285714, rs2285713, and rs11728699) in PLA2G12A were selected and genotyped. Our results showed a significant association between ASD and the rs251684 variant of PLA2G4C. The rs251684 polymorphism of PLA2G4C may be associated with Autism Spectrum Disorder risk. PMID: 27611910
- The A allele in PLA2G4C single nucleotide polymorphism (rs1549637) is associated with a worse prognosis in patients with colorectal cancer, especially in stage II. PMID: 26364726
- site-specific cytosine methylation of the CpT of PLA2G4C may play a role in the pathogenesis of schizophrenia. PMID: 22878031
- These findings suggest that IVC-PLA(2) is involved in regulations of macrophage differentiation and macrophage polarization. PMID: 22108055
- these results suggest that cPLA(2)gamma plays an important role in cancer cell chemotaxis. PMID: 21600875
- Findings suggest that variation in PLA2G4C may influence preterm birth risk by increasing levels of prostaglandins, which are known to regulate labor. PMID: 21184677
- cPLA(2) has a role in the induction of cell autonomous cellular immunity to Chlamydia PMID: 20452986
- locus showed a weak association with schizophrenia in a Chinese population PMID: 20016400
- Novel PLA2G4C polymorphism as a molecular diagnostic A minisatellite polymorphism in the untranslated region of exon 1, with allelic variants that have one, two or three 27-bp repeats PMID: 11958371
- enzymatic properties PMID: 12039969
- TNF-alpha & IFN-gamma induce gene expression of a novel cytosolic PLA(2) IVC in human airway epithelial cells. The possibility that it is involved in cytokine-mediated inflammation in the respiratory tract is inferred. PMID: 12396716
- Down-regulation of Phospholipase A2 is associated with colon tumorigenesis PMID: 15788676
- identification of its remarkable substrate selectivity that results in the highly selective generation of 2-arachidonoyl lysophosphatidylcholine PMID: 15908428
- results indicate that complete C-terminal processing is important for the functional expression of cPLA2, although not for its membrane localization PMID: 15944408
- Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells PMID: 16882668
- iPLA2gamma has roles in the lipid plasticity of myocardium, in generating signaling metabolites, and in modulating energy storage and utilization in myocardium in different metabolic contexts PMID: 17213206
- Single nucleotide polymorphism is asociated with schizzophrenia in a Chinese population. PMID: 17417066
- endometrial cell PGE2 biosynthesis was associated with PLA2G4C expression and activity PMID: 17459165
- The subcellular localization and enzymatic properties of cPLA2gamma with C-terminal FLAG-tag, was examined. PMID: 19501189
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亞細胞定位：Cell membrane; Lipid-anchor. Endoplasmic reticulum membrane; Lipid-anchor. Mitochondrion membrane; Lipid-anchor. Lipid droplet.
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組織特異性：Highly expressed in heart and skeletal muscle.
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數據庫鏈接：
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