PIP4K2A Antibody
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中文名稱：PIP4K2A兔多克隆抗體
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貨號：CSB-PA018022GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：1 phosphatidylinositol 4 phosphate 5 kinase 2 alpha antibody; 1 phosphatidylinositol 4 phosphate 5 kinase antibody; 1 phosphatidylinositol 4 phosphate kinase antibody; 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha antibody; 4 5 kinase B isoform antibody; 4 5 kinase C isoform antibody; 4 5 kinase isoform 2 alpha antibody; Diphosphoinositide kinase 2 alpha antibody; Diphosphoinositide kinase 2-alpha antibody; FLJ13267 antibody; Phosphatidylinositol 4 phosphate 5 kinase type 2 alpha antibody; Phosphatidylinositol 4 phosphate 5 kinase type II alpha antibody; Phosphatidylinositol-5-phosphate 4-kinase type II alpha antibody; Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha antibody; PI(5)P 4-kinase type II alpha antibody; PI42A_HUMAN antibody; PI5P4KA antibody; PIP4K2A antibody; PIP4KII-alpha antibody; PIP5K2 antibody; PIP5K2 alpha antibody; PIP5K2A antibody; PIP5KII alpha antibody; PIP5KII-alpha antibody; PIP5KIIA antibody; PIP5KIII antibody; PIPK antibody; PtdIns antibody; PtdIns(4)P-5-kinase B isoform antibody; PtdIns(4)P-5-kinase C isoform antibody; PtdIns(5)P-4-kinase isoform 2-alpha antibody; Type II phosphatidylinositol 4 phosphate 5 kinase 53 K isoform antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human PIP4K2A
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities. May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level. In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress. Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. Negatively regulates insulin signaling through a catalytic-independent mechanism. PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3.
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基因功能參考文獻：
- Recombinant PIP4K2A has the RNA binding activity and can associate specifically with Plasmodium 3'UTR RNAs. PMID: 29518392
- the rs7088318 (PIP4K2A) and rs2239633 (CEBPE) polymorphisms were not associated with ALL risk. PMID: 28476190
- meta-analysis of association of SNPs rs7088318 and rs4748793 and acute lymphoblastic leukemia susceptibility PMID: 27149463
- PIP5K2A is possibly involved in a mechanism protecting against tardive dyskinesia-inducing neurotoxicity. PMID: 25548108
- The diplotype ATTGCT/ATTGCT of the PIP4K2A gene confers approximately three-times higher incomplete responsiveness towards antipsychotics in severely ill patients. PMID: 25025909
- PIP4K2A to be essential for the clonogenic and leukemia-initiating potential of human AML cells, and for the clonogenic potential of murine MLL-AF9 AML cells. PMID: 24681948
- We also showed that PIPKIIalpha silencing can induce alpha and gamma globin expression and decrease cell proliferation in K562 cells. PMID: 24788727
- Overexpression of type 2A PI(4)P5-kinase (PIP5K 2A) significantly reduced tamoxifen inhibition of Kv7.2/Kv7.3 and Kv7.2 R463Q channels. PMID: 24086693
- The data suggest that PI5P4Ka N251S does not significantly differ in activity from the wild-type enzyme, throwing a new light on its association with schizophrenia. PMID: 24081551
- Knocking down PI5P4Kalpha and beta in a breast cancer cell line bearing an amplification of the gene encoding PI5P4K beta and deficient for p53 impaired growth on plastic and in xenografts. PMID: 24209622
- Variation at 10p12.2 (PIP4K2A) and 10p14 (GATA3) influences risk of acute lymphoblastic anemia and tumor subtype. (Meta-analysis) PMID: 23996088
- PIP5K2A variant influences susceptibility to schizophrenia in the Russian population of Siberia. Authors studied 355 patients with schizophrenic disorders from the Russian population of Siberia. PMID: 23739505
- The present study demonstrated that expression of PIP4K2A mRNA is significantly increased in LCL derived from patients with schizophrenia PMID: 21377334
- Studies indicate that the gene PIP5K2A was significantly elevated in stroma cells in distant metastasis group, compared to stroma in no distant metastasis group. PMID: 21124964
- PIP4Kbeta interacts with and modulates nuclear localization of the PIP4Kalpha. PMID: 20583997
- A homogeneous sample of 280 schizophrenia patients and 230 healthy controls of Hungarian, Caucasian descent were genotyped for polymorphisms in schizophrenia candidate genes NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A. PMID: 19937977
- study supports a minor role for PIP4K2A in schizophrenia etiology in the Irish population PMID: 19475563
- PIP5K2A is a novel signaling element in the regulation of EAAT3 activity PMID: 19644675
- translocation by protein kinase C is required for platelet alpha-granule secretion PMID: 12509423
- Single nucleotide polymorphism is associated with schizophfenia. PMID: 16801950
- The strongest evidence for schizophrenia association was found for the A-allele of SNP rs10828317 in the PIP5K2A gene, which was associated with both clinical subtypes. This SNP leads to a change in protein composition. PMID: 17410640
- PIP5K2A gene is implicated in schizophrenia in Chinese population PMID: 17555944
- rs11013052 was significantly associated with schizophrenia in this Indonesian family sample PMID: 18314871
- unlike PtdIns5P production enhanced by cell stress, we show that this pool of PtdIns5P is specifically regulated by the inositol lipid kinase PIP4K2a PMID: 18364242
- We find that wild-type PIP5K2A but not the schizophrenia-associated mutant (N251S)-PIP5K2A activates heteromeric KCNQ2/KCNQ3 and KCNQ3/KCNQ5, the molecular correlate of neuronal M channels. PMID: 18545987
- PIP4KIIA may be one of the factors related to the regulation of the beta-globin gene expression and the different levels of Hb H in alpha-thalassemic patients PMID: 19656170
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亞細胞定位：Cell membrane. Nucleus. Lysosome. Cytoplasm. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment.
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組織特異性：Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine.
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