PHF10 Antibody

中文名稱：

PHF10兔多克隆抗體
貨號：

CSB-PA017898LA01HU
規格：

￥440
圖片：
Western blot
All lanes: PHF10 antibody at 8µg/ml
Lane 1: Hela whole cell lysate
Lane 2: 293T whole cell lysate
Lane 3: A2780 whole cell lysate
Lane 4: U251 whole cell lysate
Lane 5: A549 whole cell lysate
Lane 6: A375 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 57, 56, 52 kDa
Observed band size: 57 kDa

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA017898LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA017898LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA017898LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PHF10 Polyclonal antibody
Uniprot No.：

Q8WUB8
基因名：

PHF10
別名：

BAF45a antibody; BRG1-associated factor 45a antibody; FLJ10975 antibody; MGC111009 antibody; PHD finger protein 10 antibody; PHD finger protein 10; isoform a antibody; PHD zinc finger protein XAP135 antibody; Phf10 antibody; PHF10_HUMAN antibody; XAP135 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human PHD finger protein 10 protein (151-360AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PHF10 Antibody (CSB-PA017898LA01HU)，的標記方式是Non-conjugated。對于PHF10 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA017898LB01HU	PHF10 Antibody, HRP conjugated	ELISA
FITC	CSB-PA017898LC01HU	PHF10 Antibody, FITC conjugated
Biotin	CSB-PA017898LD01HU	PHF10 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
基因功能參考文獻：
1. We studied the expression of S100A4 and the total PHF10 protein in some human cancer cell lines. We have found that, in the cell lines studied, the PHF10 expression is correlated with the S100A4 expression. PMID: 27193724
2. Phosphorylation of PHF10 isoforms occurs while they are incorporated as a subunit of the PBAF complex, and therefore phosphorylation of PHF10 isoforms may play an essential role in regulation of PBAF complex's function and mechanism of action. PMID: 27239853
3. The study demonstrates the existence of functionally different PBAF complexes in mammalian cell. It also provides an insight into the molecular structure and role of human PHF10/BAF45a and characterizes it as an essential PBAF subunit. PMID: 24763304
4. PHF10 repressed caspase-3 expression and impaired the programmed cell death pathway in human gastric cancer at the transcriptional level. PMID: 20530714
5. Data show that that PHF10 is required for cell growth. PMID: 20068294
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亞細胞定位：

Nucleus.
蛋白家族：

SAYP family
數據庫鏈接：

HGNC: 18250

OMIM: 613069

KEGG: hsa:55274

STRING: 9606.ENSP00000341805

UniGene: Hs.435933

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