PFKFB2 Antibody
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中文名稱：PFKFB2兔多克隆抗體
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貨號：CSB-PA796746
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規(guī)格：￥2024
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圖片：
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Western blot analysis of extracts from Jurkat cells, using PFKFB2 antibody.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) PFKFB2 Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthesized peptide derived from N-terminal of Human PFKFB2.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Synthesis and degradation of fructose 2,6-bisphosphate.
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基因功能參考文獻(xiàn)：
- UCA1/miR-182/PFKFB2 axis modulates chemokine CXCL14 secretion, glycolysis and invasion of glioma cells in glioblastoma-associated stromal cells . PMID: 29655792
- Crystal structure of human and cattle heart PFKFB2 and the inhibitory influence of citrate on substrate binding has been described. PMID: 27802586
- Variation in PFKFB2 appears to reduce PFKFB2 expression in adipose and kidney tissues, and thereby increase risk for adiposity and diabetic nephropathy. PMID: 25662186
- Highly expressed PFKFB2 protein is associated with hepatocellular carcinoma. PMID: 24568531
- bifunctionality of PFK-2/FBPase-2 complements the metabolic zonation of the liver by ensuring coherent switching in response to insulin and glucagon. PMID: 24634222
- amino acids stimulate Fru-2,6-P2 synthesis by Akt-dependent PFKFB2 phosphorylation and activation and show how signaling and metabolism are inextricably linked. PMID: 23457334
- A persistent increase in 6-phosphofructo-2-kinase produced by a change in PFK-2/FBPase-2 isoform expression that may play an important role in the regulation of muscle glycolysis. PMID: 22241065
- Suggest that PFKFB2 is not an essential upstream regulator of the anti-leukemic effects of glucocorticoids. PMID: 21092265
- induction of de novo lipid synthesis by androgen requires transcriptional up-regulation of HK2 and PFKFB2, and phosphorylation of PFKFB2 generated by the PI3K/Akt signal pathway to supply the source for lipogenesis from glucose in prostate cancer cells. PMID: 20958264
- Human islets expressed the PFKFB2 and PFKFB3 isoforms. PFK-2/FBPase-2 protein rather than its product fructose 2,6-P(2) is the over-riding determinant of glucose-induced insulin secretion through regulation of glucokinase activity PMID: 18039179
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蛋白家族：Phosphoglycerate mutase family
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組織特異性：Heart.
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數(shù)據(jù)庫鏈接：
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