PES1 Antibody, Biotin conjugated
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中文名稱：PES1兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA017791LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PES1 Polyclonal antibody
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Uniprot No.：
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基因名：PES1
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別名：FLJ43790 antibody; Homo sapiens pescadillo mRNA complete cds antibody; PES antibody; PES 1 antibody; pes1 antibody; PESC_HUMAN antibody; Pescadillo (zebrafish) homolog 1 containing BRCT domain antibody; Pescadillo homolog 1 antibody; Pescadillo homolog 1 containing BRCT domain (zebrafish) antibody; Pescadillo homolog antibody; Pescadillo ribosomal biogenesis factor 1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Pescadillo homolog protein (378-588AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
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基因功能參考文獻：
- posttranslational modification of PES1 by SUMOylation may serve as a key factor that regulates the function of PES1 in vivo PMID: 27409667
- PES1 may play an important role in development of gastric cancer. PMID: 26423399
- PES1 may play important role in the progression of ovarian cancer by inversely regulating the ERalpha and ERbeta expression. PMID: 24376209
- these results uncover a potential role of PES1 in chemoresistance by regulating DNA damage response in colorectal cancer cells. PMID: 23333390
- Upstream of c-Jun, it was revealed that c-Jun NH2-terminal kinases (JNK) is essential for controlling PES1 expression PMID: 22860098
- expression of PES1 correlated positively with ERalpha expression and negatively with ERbeta expression and predicted good clinical outcome in breast cancer PMID: 22820289
- The physical interaction between B23 and PES1 implies that they may participate in ribosome biogenesis in a protein complex. PMID: 20011973
- pescadillo might play a role in promoting the proliferation and carcinogenesis of human breast cancer, and thereby might be a potential target for human breast cancer treatment. PMID: 19764998
- Mechanisms for the ability of Pes1 to transform cells, and its failure to immortalize them. PMID: 15273728
- RRB1 interacts with YPH1 (yeast pescadillo homologue 1) and other members of the Yph1 complex PMID: 15467761
- Pes1 and Bop1 form a stable complex with a novel member, WDR12 (PeBoW complex). PMID: 16043514
- Results describe the role of PeBoW-specific proteins Pes1, Bop1, and WDR12 in complex assembly and stability, nucleolar transport, and pre-ribosome association. PMID: 17353269
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亞細胞定位：Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome.
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蛋白家族：Pescadillo family
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組織特異性：Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin.
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數據庫鏈接：
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