PDLIM7 Antibody
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中文名稱：PDLIM7兔多克隆抗體
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貨號：CSB-PA017737GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：PDLIM7
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別名：1110003B01Rik antibody; Enigma antibody; LIM domain protein antibody; LIM domain protein enigma antibody; LIM mineralization protein 1 antibody; Lim mineralization protein 3 antibody; LIM mineralization protein antibody; LMP 1 antibody; LMP antibody; LMP1 antibody; LMP3 antibody; PDLI7_HUMAN antibody; PDLIM 7 antibody; Pdlim7 antibody; PDZ and LIM doamin protein 7 antibody; PDZ and LIM domain 7 antibody; PDZ and LIM domain protein 7 antibody; Protein enigma antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human PDLIM7
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway.
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基因功能參考文獻：
- In enigma siRNA-transfected cells, cell viability, and the protein levels of AKT and survivin decreased. PMID: 29848705
- LMOD1, SYNPO2, PDLIM7, PLN, and SYNM down-regulation reflect the altered phenotype of smooth muscle cells in vascular disease and could be early sensitive markers of SMC dedifferentiation. PMID: 27470516
- Molecular basis of the overactive osteogenic process may at least in part involve a deregulation of the LMP-related pathway in calvarial cells. PMID: 22982077
- The results showed that LMP-1 inhibited cell apoptosis and induced survivin expression in nasal natural killer/T-cell lymphoma PMID: 25760809
- The results suggest local transduction with LMP-1 gene promotes osteogenesis and mineralization in distraction osteogenesis. PMID: 25641592
- LMP-1 mRNA level was regulated in a dose-dependent manner after transfection PMID: 25336289
- These results are consistent with a model in which binding of OspE to PDLIM7 during infection regulates the activity of PKC isoforms that bind to the PDLIM7 LIM domain. PMID: 25124035
- LMP1 expression suppressed the expression of Runx2 and BMP-2 in OS cells. PMID: 24762763
- High Enigma expression is associated with breast neoplasms. PMID: 24466333
- A direct interaction of Jab1 with LMP-1, is reported. PMID: 24078030
- Gene transfer of LMP3 upregulated Alkaline Phosphatase, Bone Sialoprotein and BMP2 gene expression and increased in vitro matrix mineralization in human PDL cell line. PMID: 22241179
- LMP3 induced the successful osteogenic differentiation of AFSC by inducing the expression of osteogenic markers and osteospecific transcription factors. PMID: 23097599
- findings indicate the existence of a new cell cycle-associated signaling pathway in which LMP1 regulates ERK-mediated Op18/stathmin signaling PMID: 22417000
- results suggested that LMP3 could affect the fine balance between cell proliferation/differentiation of mesenchymal cells mostly by modulating the TGF-beta1 signaling pathway PMID: 21061915
- SRF and Enigma coexpressed with MDM2 but not p53 in several liver and stomach tumors. PMID: 21060154
- LMP1 is a downstream gene of TGF-beta1, involved in periodontal ligament cell proliferation. PMID: 20348040
- isolated the complementary DNA (cDNA) for the human homologue of LMP-1 from an adult human heart cDNA library and showed that when overexpressed it is osteoinductive PMID: 11874232
- LIM-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads PMID: 16611643
- Enigma is involved in insulin-induced Glut 4 translocation by regulating cortical actin remodeling. PMID: 16803868
- Authors hypothesize that the HIV-1 TAT interacting protein can fuse with PDLIM7 and that the fusion proteins could be easily transduced through biological membranes and have biological activity. PMID: 17126496
- When transferred into mouse muscle fibers, a truncated form of LMP-1 induces pluripotent myoblastic C2C12 cells to differentiate into osteoblastic lineage. PMID: 17805464
- LMP-1 was expressed primarily in predentin, odontoblasts and blood vessel endothelial cells of healthy teeth. LMP-1 expression was found in unmineralized reparative dentin, odontoblast-like cells and pulp fibroblasts in teeth with caries and pulpitis. PMID: 18215669
- These studies provide evidence that overexpression of IGFBP-6 suppresses human and murine osteoblast differentiation, that IGFBP-6 and LMP-1 physically interact, and supports the conclusion that this interaction may be functionally relevant. PMID: 18395833
- LMP1 mediates serine 256 phosphorylation and nuclear entry of Annexin A2 via PLC-PKCalpha/PKCbeta pathway. PMID: 18412141
- Immunofluorescence stained cell numbers are increased after 20 MOI AdLMP1-GFP infection concordant with upregulation of mRNA expression. PMID: 18618069
- absence of any hexosamines (N-acetyl glucosamine or N-acetyl galactosamine) in chemical composition analysis of LMP-1 protein revealed that there is little or no post-translational glycosylation of the LMP-1 polypeptide in lung carcinoma cells PMID: 18989571
- PAR-2 is a possible mediator cooperating with LMP-1 and MMP9 to influence the progression of nasopharyngeal carcinoma by inducing angiogenesis and promoting lymph node metastasis. PMID: 19269113
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亞細胞定位：Cytoplasm. Cytoplasm, cytoskeleton.
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組織特異性：Isoform 1 and isoform 2 are expressed ubiquitously, however, isoform 2 predominates in skeletal muscle, isoform 1 is more abundant in lung, spleen, leukocytes and fetal liver.
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數據庫鏈接：
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