PDF Antibody, FITC conjugated
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中文名稱：PDF兔多克隆抗體, FITC偶聯
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貨號：CSB-PA872538LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PDF Polyclonal antibody
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Uniprot No.：
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基因名：PDF
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別名：PDF antibody; PDF1A antibody; Peptide deformylase antibody; mitochondrial antibody; EC 3.5.1.88 antibody; Polypeptide deformylase antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Peptide deformylase, mitochondrial protein (16-143AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Removes the formyl group from the N-terminal Met of newly synthesized proteins.
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基因功能參考文獻：
- compound M7594_0037 exhibited potent anticancer activities against HeLa, A549 and MCF-7 cell lines with IC50s of 35.26, 29.63 and 24.63 muM, respectively. Molecular docking studies suggested that M7594_0037 and its three derivatives could interact with Human peptide deformylase by several conserved hydrogen bonds. PMID: 27023495
- c-myc regulated the expression of human PDF. PMID: 24675470
- This is the first report showing that PDF is over-expressed in breast, colon, and lung cancers PMID: 23815882
- these data reveals that PDF has several transcription start sites, the most important of which only 18 bp from the initiation codon. PMID: 22554513
- the origin, evolution and preservation of the COG8/PDF same-strand overlap follow similar mechanistic steps as those documented for antisense overlaps where gain and/or loss of splice sites and polyadenylation signals seems to drive the process. PMID: 21805148
- The inhibition of HsPDF may provide an explanation for the mechanism by which actinonin is cytotoxic against various human tumor cell lines. PMID: 14637138
- Despite the lack of true S2' and S3' binding pockets, confirmed through peptide binding modeling, enzyme kinetics suggest a combined contribution from P2'and P3' positions of a formylated peptide substrate to turnover. PMID: 19236878
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亞細胞定位：Mitochondrion.
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蛋白家族：Polypeptide deformylase family
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組織特異性：Ubiquitous.
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數據庫鏈接：
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