PDE8A Antibody, Biotin conjugated

說明書

中文名稱：

PDE8A兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA525315LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PDE8A Polyclonal antibody
Uniprot No.：

O60658
基因名：

PDE8A
別名：

5''-cyclic phosphodiesterase 8A antibody; cAMP specific cyclic nucleotide phosphodiesterase 8A antibody; FLJ16150 antibody; High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8A antibody; High affinity cAMP-specific and IBMX-insensitive 3'' antibody; HsT19550 antibody; PDE 8A antibody; PDE8A antibody; PDE8A_HUMAN antibody; Phosphodiesterase 8A antibody; Phosphodiesterase8A antibody; Weakly similar to 3'5' cyclic nucleotide phosphodiesterase antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A protein (596-829AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine.
基因功能參考文獻：
1. SNPs within genes SCHIP1 and PDE8A were associated with measures of facial size in both the GWAS and replication cohorts and passed a stringent genomewide significance threshold adjusted for multiple testing of 34 correlated traits. For both SCHIP1 and PDE8A, we demonstrated clear expression in the developing mouse face by both whole-mount in situ hybridization and RNA-seq PMID: 27560698
2. PDE8A supports HIV-1 replication in macrophages PMID: 25295610
3. a novel and critical role for phosphodiesterases in moderating local concentrations of cAMP in microdomains and signal resetting PMID: 25229150
4. PDE8A can bind tightly to Raf-1, regulate Raf-1 phosphorylation on S259, and, in so doing, regulate the cross-talk node whereby cAMP exerts an inhibitory effect on Raf-1 signaling, retarding subsequent ERK phosphorylation and activation. PMID: 23509299
5. PDE8 activity can be modulated by a kinase PMID: 22673573
6. Polymorphism in PDE8A affects HIV-1 replication in primary macrophages. PMID: 21920574
7. Comparison of enzymatic characterization and gene organization of PDE8B and PDE8A. PMID: 12681444
8. in vitro and in vivo experiments demonstrated that the association with IkappaB greatly enhanced the enzyme activity of PDE8A1 PMID: 15596729
9. kinetic properties of the highly active PDE8A1 catalytic domain prepared from refolding and its crystal structures in the unliganded and 3-isobutyl-1-methylxanthine (IBMX) bound forms at 1.9 and 2.1 A resolutions PMID: 18983167
10. The findings exclude a significant role for PDE8A as a PCOS candidate gene, and as a Las major determinant of androgen levels in women. PMID: 19482904
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蛋白家族：

Cyclic nucleotide phosphodiesterase family, PDE8 subfamily
組織特異性：

Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.
數據庫鏈接：

HGNC: 8793

OMIM: 602972

KEGG: hsa:5151

STRING: 9606.ENSP00000311453

UniGene: Hs.9333

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