PDE1B Antibody, FITC conjugated

說明書

中文名稱：

PDE1B兔多克隆抗體, FITC偶聯(lián)
貨號(hào)：

CSB-PA27759C0Rb
規(guī)格：

￥880
其他：

產(chǎn)品詳情
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靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PDE1B Polyclonal antibody
Uniprot No.：

Q01064
基因名：

PDE1B
別名：

5''-cyclic nucleotide phosphodiesterase 1B antibody; 63 kDa Cam PDE antibody; 63 kDa Cam-PDE antibody; Calcium/calmodulin dependent 3' 5' cyclic nucleotide Phosphodiesterase 1B antibody; Calcium/calmodulin stimulated cyclic nucleotide phosphodiesterase antibody; Calcium/calmodulin-dependent 3'' antibody; Calmodulin stimulated phosphodiesterase PDE1B1 antibody; Cam PDE 1B antibody; Cam PDE1B antibody; Cam-PDE 1B antibody; PDE 1B antibody; PDE1B antibody; PDE1B_HUMAN antibody; PDE1B1 antibody; PDES 1B antibody; PDES1B antibody; Phosphodiesterase 1B antibody; Phosphodiesterase 1B calmodulin dependent antibody; Presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B protein (1-277AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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靶點(diǎn)詳情

功能：

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
基因功能參考文獻(xiàn)：
1. The c.1618G>A, p.Gly540Ser substitution in CNGA3 was identified as the causative mutation for a novel form of ACHM in Awassi sheep. Gene augmentation therapy restored vision in the affected sheep. This novel mutation provides a large-animal model that is valid for most human CNGA3 ACHM patients; the majority of them carry missense rather than premature-termination mutations. PMID: 28282490
2. Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation. PMID: 15625104
3. PDE1B2 regulates a subset of phenotypic changes that occur upon phorbol-12-myristate-13-acetate-induced differentiation and likely also plays a role in differentiated macrophages by regulating agonist-stimulated cGMP levels PMID: 16407168
亞細(xì)胞定位：

Cytoplasm.
蛋白家族：

Cyclic nucleotide phosphodiesterase family, PDE1 subfamily
數(shù)據(jù)庫鏈接：

HGNC: 8775

OMIM: 171891

KEGG: hsa:5153

STRING: 9606.ENSP00000243052

UniGene: Hs.530871

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