PCSK2 Antibody, Biotin conjugated
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中文名稱：PCSK2兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA017642LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PCSK2 Polyclonal antibody
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Uniprot No.：
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基因名：PCSK2
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別名：KEX2 like endoprotease 2 antibody; KEX2-like endoprotease 2 antibody; NEC 2 antibody; NEC2 antibody; NEC2_HUMAN antibody; Neuroendocrine convertase 2 antibody; PC2 antibody; PCSK2 antibody; Prohormone convertase 2 antibody; Proprotein convertase 2 antibody; Proprotein convertase subtilisin/kexin type 2 antibody; SPC2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Neuroendocrine convertase 2 protein (267-391AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.
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基因功能參考文獻：
- PCSK2 gene polymorphisms are associated with pleiotropic effects on various traits of glucose homeostasis and incident diabetes. PMID: 26607656
- FAM20C plays a role in 7B2-mediated proPC2 activation by phosphorylating residue Thr111; and that 7B2 function is regulated by alternative splicing. PMID: 25811241
- in the processing of hypothalamic neuropeptides in huntington disease may partially arise from decreased PC1/3 and PC2 expressions. PMID: 24226266
- variant of the PCSK2 gene was associated with reduced glucose-stimulated insulin secretion, but also with lower glucagon levels, which could potentially counteract the effects of decreased insulin secretion on the risk of type 2 diabetes PMID: 23011353
- The association of risk allele rs2021785 at PCSK2 with type 2 diabetes exists in a Han Chinese population PMID: 21437630
- differential gene expression profiles revealed more abundant mRNA expression in ectopic ACTH syndrome than in Cushing disease of proprotein convertase-2 PMID: 21383526
- PC1/3 governs the endocrine, and PC2 the neuronal processing, of proCCK, whereas PC5/6 contributes only to a modest endocrine synthesis of CCK-22. PMID: 18096669
- SEMA3F, CLEC16A, LAMA3, and PCSK2 variants have roles in myocardial infarction in Japanese individuals PMID: 20036365
- A marked decrease in the ratio of the PC2 precursor to the total enzymatic pool is observed in the frontal cortex of Alzheimer patients; however, the content and enzymatic activity of the PC2 mature form are similar in Alzheimer patients and controls. PMID: 14614908
- concluded that there are two novel TRE-like sequences in the hPC2 promoter and that these regions act in concert in a unique manner to facilitate the effects of thyroid hormone and 9-cis-retinoic acid on PC2 PMID: 15585599
- Single nucleotide polymorphisms in PCSK2 is associated with type 2 diabetes PMID: 17618154
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亞細胞定位：Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Localized in the secretion granules.
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蛋白家族：Peptidase S8 family, Furin subfamily
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數據庫鏈接：
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