PCID2 Antibody, Biotin conjugated

說(shuō)明書(shū)

產(chǎn)品詳情

產(chǎn)品名稱(chēng)：

Rabbit anti-Homo sapiens (Human) PCID2 Polyclonal antibody
Uniprot No.：

Q5JVF3
基因名：

PCID2
別名：

CSN12 like protein antibody; CSN12-like protein antibody; DKFZp686C20226 antibody; F10 antibody; FLJ11305 antibody; FLJ99362 antibody; HT004 antibody; MGC16774 antibody; PCI domain containing 2 antibody; PCI domain containing protein 2 antibody; PCI domain-containing protein 2 antibody; PCID2 antibody; PCID2_HUMAN antibody; RP11 - 98F14.6 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human PCI domain-containing protein 2 protein (2-250AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Biotin
克隆類(lèi)型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (Probable). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.
基因功能參考文獻(xiàn)：
1. Data show that PCI domain-containing protein 2 (Pcid2) controls lymphoid lineage commitment through the regulation of Snf2-related CREBBP activator protein (SRCAP) remodelling activity. PMID: 29138493
2. Pcid2 is present in the CBP/p300-EID1 complex to control the switch balance of mouse and human embryonic stem cells through modulation of EID1 degradation. PMID: 24167073
3. First discovery of specific novel functions for PCID2 other than mRNA export and components of the TREX-2 complex serve alternative shared roles in the regulation of nuclear transport and cell cycle progression. PMID: 24291146
4. validated occurrence of an unusual TG 3' splice site in intron 2 PMID: 17672918
亞細(xì)胞定位：

Cytoplasm. Nucleus, nuclear pore complex.
蛋白家族：

CSN12 family
數(shù)據(jù)庫(kù)鏈接：

HGNC: 25653

OMIM: 613713

KEGG: hsa:55795

STRING: 9606.ENSP00000337405

UniGene: Hs.508769

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