PCGF6 Antibody, HRP conjugated

說明書

中文名稱：

PCGF6兔多克隆抗體, HRP偶聯
貨號：

CSB-PA871612LB01HU
規(guī)格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PCGF6 Polyclonal antibody
Uniprot No.：

Q9BYE7
基因名：

PCGF6
別名：

MBLR antibody; Mel18 and Bmi1 like RING finger protein antibody; Mel18 and Bmi1-like RING finger antibody; Pcgf6 antibody; PCGF6_HUMAN antibody; Polycomb group RING finger protein 6 antibody; RING finger protein 134 antibody; RNF134 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Polycomb group RING finger protein 6 protein (9-70AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.
基因功能參考文獻：
1. Pcgf6 acts as a master regulator to maintain embryonic stem cell identity. PMID: 27247273
2. regulation by cell cycle-dependent phosphorylation PMID: 12167161
3. Thus, we did not find evidence for uniquely interacting partner proteins using this approach, but did identify four new lamin A/C interactive partners PMID: 16248985
4. Study shows that JARID1d and MBLR occupy human Engrailed 2 gene and regulate its expression and histone H3 lysine 4 methylation levels. PMID: 17320162
5. MEL-18 bound to HSF2 inhibits its sumoylation by binding to and inhibiting the activity of UBC9 enzymes in the vicinity of HSF2. PMID: 18211895
6. Mel-18 overexpression showed reduced glycogen synthase kinase-3beta phosphorylation, beta-catenin nuclear localization, T-cell factor/lymphoid enhancer factor promoter activity, and cyclin D1 mRNA level PMID: 18519679
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亞細胞定位：

Nucleus.
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 21156

OMIM: 607816

KEGG: hsa:84108

STRING: 9606.ENSP00000358862

UniGene: Hs.335808

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