PCBD1 Antibody
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中文名稱：PCBD1兔多克隆抗體
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貨號：CSB-PA017514GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：PCBD1
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別名：4 alpha hydroxy tetrahydropterin dehydratase antibody; 4-alpha-hydroxy-tetrahydropterin dehydratase antibody; 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) antibody; 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha antibody; DCoH antibody; Dimerization cofactor of hepatic nuclear factor 1 alpha antibody; Dimerization cofactor of hepatocyte nuclear factor 1 alpha antibody; Dimerization cofactor of hepatocyte nuclear factor 1-alpha antibody; Dimerization cofactor of HNF1 antibody; Dimerizing cofactor for HNF1 antibody; PCBD 1 antibody; PCBD antibody; PCBD1 antibody; PCD antibody; Phenylalanine hydroxylase stimulating protein antibody; Phenylalanine hydroxylase-stimulating protein antibody; PHS antibody; PHS_HUMAN antibody; Pterin 4 alpha carbinolamine dehydratase antibody; Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) antibody; Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha antibody; Pterin carbinolamine dehydratase antibody; Pterin-4-alpha-carbinolamine dehydratase antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human PCBD1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity. Also acts as a coactivator for HNF1B-dependent transcription.
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基因功能參考文獻：
- We provide the first genetic evidence that PCBD1 mutations can cause early-onset nonautoimmune diabetes with features similar to dominantly inherited HNF1A-diabetes. PMID: 24848070
- Coactivator of the HNFB1 (HNF1 homeobox B)-mediated transcription is necessary for fine tuning ATPase Na+/K+ transporting gamma 1 polypeptide (FXYD2) transcription in the distal convoluted tubule PMID: 24204001
- Pcbd1 is a moonlighting protein that has dehydratase activity in addition to functioning as a cofactor which regulates HNF1alpha. PMID: 9092652
- variants of the hepatocyte nuclear factor-1beta (HNF-1beta / TCF2) and the dimerization cofactor of HNF-1 (DcoH/PCBD) genes in relation to type 2 diabetes mellitus and beta-cell function PMID: 11668623
- Data reveal DCoH/HNF-1 alpha expression and transcriptional activity in human epidermal melanocytes in vitro and in situ and identified tyrosinase, the key enzyme for pigmentation, as a new transcriptional target. PMID: 12565907
- Albumin colocalized together with its transcription factor PCD/DCoH/HNF-1alpha in suprabasal keratinocytes in human full-thickness skin sections and in keratinocytes cultured in serum-free medium. PMID: 15740590
- Properties of dehydratase/DCoHalpha are consistent with hypothesis that activity of this isozyme could account for relatively mild symptoms reported for patients with a defect in dehydratase/DCoH PMID: 16423549
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相關疾病：Hyperphenylalaninemia, BH4-deficient, D (HPABH4D)
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亞細胞定位：Cytoplasm. Nucleus.
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蛋白家族：Pterin-4-alpha-carbinolamine dehydratase family
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數據庫鏈接：
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