PANK1 Antibody, HRP conjugated
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中文名稱：PANK1兔多克隆抗體, HRP偶聯
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貨號：CSB-PA017421LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PANK1 Polyclonal antibody
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Uniprot No.：
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基因名：PANK1
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別名：coaA antibody; hPanK antibody; hPanK1 antibody; PANK antibody; PANK1 antibody; PANK1_HUMAN antibody; PANK1a antibody; PANK1b antibody; PanK1beta antibody; Pantothenate kinase 1 antibody; Pantothenate kinase antibody; Pantothenic acid kinase 1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Pantothenate kinase 1 protein (462-582AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.
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基因功能參考文獻：
- p53 plays an important role in regulating energy homeostasis through transcriptional control of PANK1. PMID: 23343762
- PANK deficiency leads to abnormalities in F-actin organization. PMID: 22912811
- molecular cloning and characterization of a new human PanK gene PMID: 11809413
- alternative splicing product PMID: 12379284
- PPARalpha transcription factor as a major factor governing hepatic CoA levels by specific modulation of PANK1alpha gene expression PMID: 14523052
- analysis of the homodimeric structures of the catalytic cores of PanK1alpha and PanK3 in complex with acetyl-CoA and the the structural effects of the PanK2 mutations that have been implicated in neurodegeneration PMID: 17631502
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亞細胞定位：Cytoplasm.; [Isoform 1]: Nucleus. Nucleus, nucleolus.; [Isoform 2]: Cytoplasm, cytosol. Cytoplasmic vesicle, clathrin-coated vesicle. Recycling endosome.
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蛋白家族：Type II pantothenate kinase family
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組織特異性：[Isoform 1]: Expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis.; [Isoform 2]: Detected at much lower levels in kidney, liver, brain and testis and not detected in heart or skeletal muscle.
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