ORC6 Antibody

說明書

中文名稱：

ORC6兔多克隆抗體
貨號：

CSB-PA893418ESR2HU
規格：

￥440
圖片：
Western blot
All lanes: ORC6 antibody at 16μg/ml
Lane 1: Mouse spleen tissue
Lane 2: MCF-7 whole cell lysate
Lane 3: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 28 kDa
Observed band size: 28 kDa

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA893418ESR2HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ORC6 Polyclonal antibody
Uniprot No.：

Q9Y5N6
基因名：

ORC6
別名：

ORC 6 antibody; Orc6 antibody; ORC6_HUMAN antibody; ORC6L antibody; Origin recognition complex subunit 6 antibody; origin recognition complex subunit 6 homolog like antibody; origin recognition complex subunit 6 homolog like (yeast) antibody; origin recognition complex subunit 6 like (yeast) antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Origin recognition complex subunit 6 protein (1-252AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
基因功能參考文獻：
1. The 11-year-old boy with Meier-Gorlin syndrome (MGS) has a homozygous mutation in origin recognition complex, subunit 6 (ORC6) gene mapped to chromosome 16, and his father with heterozygote carrier of ORC6 gene. PMID: 28186598
2. The present report expands the clinical phenotype associated with ORC6 mutations to include severely abnormal embryological development suggesting a possible genotype-phenotype correlation. PMID: 25691413
3. our results suggest that Meier-Gorlin syndrome mutations in Orc6 impair the formation of ORC hexamers, interfering with appropriate ORC functions PMID: 24137536
4. findings show that Orc6 not only interacts with Orc1-Orc5 but also with the initiation factor Cdc6, and that Orc6 functions at different stages of the replication initiation process. PMID: 21461783
5. Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB. PMID: 21502537
6. results implicate Orc6 as an essential gene that coordinates chromosome replication and segregation with cytokinesis PMID: 12169736
7. Study using HCT116 haplo-insufficient cells and Orc2 hypomorphic cells demonstrates that the binding of human Ku to replication origins precedes that of Orc-3, -4, and -6 subunit binding. PMID: 15910003
8. Orc6 has a role in sensitizing human colon cancer cells to 5-fluorouracil and cisplatin PMID: 19112505
9. In a cross-species complementation experiment, the expression of human Orc6 in Drosophila Orc6 mutant cells rescued DNA replication, suggesting that this function of the protein is conserved among metazoans. PMID: 19541634
10. Functional studies of the Drosophila homolog PMID: 11593009
11. Functional studies of the yeast homolog PMID: 8266075
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相關疾病：

Meier-Gorlin syndrome 3 (MGORS3)
亞細胞定位：

Nucleus.
蛋白家族：

ORC6 family
數據庫鏈接：

HGNC: 17151

OMIM: 607213

KEGG: hsa:23594

STRING: 9606.ENSP00000219097

UniGene: Hs.49760

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