OPCML Antibody, Biotin conjugated
-
中文名稱：OPCML兔多克隆抗體, Biotin偶聯(lián)
-
貨號(hào)：CSB-PA621799LD01HU
-
規(guī)格：￥880
-
其他：
產(chǎn)品詳情
-
產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) OPCML Polyclonal antibody
-
Uniprot No.：
-
基因名：
-
別名：GM181 antibody; IgLON family member 1 antibody; IGLON1 antibody; OBCAM antibody; OPCM antibody; OPCM_HUMAN antibody; OPCML antibody; Opiate binding cell adhesion molecule antibody; Opioid binding cell adhesion molecule antibody; Opioid binding protein/cell adhesion molecule antibody; Opioid binding protein/cell adhesion molecule-like antibody; Opioid binding protein/cell adhesion molecule-like preprotein antibody; Opioid-binding cell adhesion molecule antibody; Opioid-binding protein/cell adhesion molecule antibody
-
宿主：Rabbit
-
反應(yīng)種屬：Human
-
免疫原：Recombinant Human Opioid-binding protein/cell adhesion molecule protein (28-322AA)
-
免疫原種屬：Homo sapiens (Human)
-
標(biāo)記方式：Biotin
-
克隆類型：Polyclonal
-
抗體亞型：IgG
-
純化方式：>95%, Protein G purified
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
-
應(yīng)用范圍：ELISA
-
Protocols：
-
儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
功能：Binds opioids in the presence of acidic lipids; probably involved in cell contact.
-
基因功能參考文獻(xiàn)：
- Here we show that, though OPCML interacts only with HER2 and not with EGFR, the interaction of OPCML with HER2 disrupts the formation of the HER2-EGFR heterodimer, and this translates into a better response to both lapatinib and erlotinib in HER2-expressing ovarian and breast cancer cell lines PMID: 28775148
- Study revealed that reduced expression of OPCML might have a significant correlation with unfavorable tumor stage and differentiation, predict poor prognosis of patients with gastric cancer. OPCML had a tumor-suppressing activity possibly via AKT/GSK3beta signaling in gastric cancer. PMID: 28407749
- OPCML and FLRT2 were further validated in an independent cohort consisting of 20 low-Gleason and 33 high-Gleason tissues. We then compared patients with biochemical recurrence (n=70) vs. those without (n=86) in a third cohort, and they showed no difference in methylation at these DMR loci PMID: 26890304
- OPCML plays an important role in gastric cancer, and may be a new prognostic indicator of gastric cancer. PMID: 27358143
- the DNA methylation levels of OPCML and SFRP1 could be potential biomarkers for diagnosis of CCA with high specificity, sensitivity, and accuracy, in particular for biopsy specimens PMID: 25652468
- The generation and cardiac phenotype of single and double heterozygous gene-targeted OPCML and Neurotrimin knockout mice. PMID: 24616287
- Detection of OPCML hypermethylation in the serum is useful for diagnosis of ovarian carcinoma. PMID: 24839818
- The OPCML tumor suppressor negatively regulates a specific spectrum of receptor tyrosine kinases in ovarian cancer cells by binding to their extracellular domain. PMID: 22585860
- A strong association was found between an intronic SNP of the OPCML gene (rs1784519) and the risk of schizophrenia in the Thai population PMID: 21833655
- opioid binding protein/cell adhesion molecule-like promoter methylation has a role in bladder carcinoma PMID: 21273058
- OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer PMID: 12819783
- Oncogenic RAS activity is directly responsible for the observed OPCML promoter hypermethylation and epigenetic gene silencing of OPCML. PMID: 16384911
- The results were confirmed at the level of mRNA and protein, and suggested that four genes (OPCML, RNASE1, YES1 and ACK1) could play a key role in the tumorigenesis and metastasis of gastric cancer. PMID: 17109515
- Hypermethylation of OPCML gene is responsible for silencing and loss of suppressor function in ovarian cancer. PMID: 17159813
- OPCML down-regulation occurs in the majority of brain tumours tested PMID: 17239010
- Results identified OPCML loci showing significant differential DNA methylation levels between tumor and non-tumor lung and highly significant hypermethylation in adenocarcinoma. PMID: 17967182
- loss of OPCML expression occurs frequently in ovarian serous carcinoma. CpG island methylation and LOH are probably two mechanisms of OPCML inactivation PMID: 18179137
- OPCML gene promoter methylation may play an important role in the carcinogenesis of cervical carcinoma. OPCML may be a cervical carcinoma-associated candidate tumor suppressor gene. PMID: 18584347
- OPCML is a broad tumor suppressor, which is frequently inactivated by methylation in multiple malignancies. PMID: 18714356
顯示更多
收起更多
-
相關(guān)疾病：Ovarian cancer (OC)
-
亞細(xì)胞定位：Cell membrane; Lipid-anchor, GPI-anchor.
-
蛋白家族：Immunoglobulin superfamily, IgLON family
-
數(shù)據(jù)庫(kù)鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
