OASL Antibody

說明書

中文名稱：

OASL兔多克隆抗體
貨號：

CSB-PA661512
規格：

￥1090
圖片：
Western Blot analysis of HELA cells using primary antibody diluted at 1:2000(4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour)
其他：

產品詳情
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靶點詳情

產品詳情

Uniprot No.：

Q15646
基因名：

OASL
別名：

2' 5' oligoadenylate synthetase like antibody; 2''-5''-OAS-related protein antibody; 2''-5''-OAS-RP antibody; 2''-5''-oligoadenylate synthase-like protein antibody; 2'-5' oligoadenylate synthetase-like 2 antibody; 2'-5'-oligoadenylate synthetase-like antibody; 59 kDa 2' 5' oligoadenylate synthetase like protein antibody; 59 kDa 2''-5''-oligoadenylate synthase-like protein antibody; 59 kDa 2'-5'-oligoadenylate synthetase-like protein antibody; M1204 antibody; Mmu-OASL antibody; OASL antibody; OASL_HUMAN antibody; Oasl2 antibody; p59 OASL antibody; p59OASL antibody; THYROID HORMONE RECEPTOR INTERACTOR 14 antibody; Thyroid receptor interacting protein 14 antibody; Thyroid receptor-interacting protein 14 antibody; TR-interacting protein 14 antibody; TRIP-14 antibody; TRIP14 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from Human OASL. at AA range: 1-50
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB,ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-2000
ELISA	1:10000-20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.
基因功能參考文獻：
1. These data uncover a promycobacterial role for STING-dependent OASL production during Mycobacterium leprae infection that directs the host immune response toward a niche that permits survival of the pathogen. PMID: 27190175
2. OASL acts as a cellular antiviral protein and RSV NS1 suppresses this function to evade cellular innate immunity and allow virus growth. PMID: 26178980
3. Primary mononuclear cells from patients with systemic sclerosis have increased basal levels of OASL and OAS2 genes. PMID: 24328427
4. these findings show a mechanism by which human OASL contributes to host antiviral responses by enhancing RIG-I activation. PMID: 24931123
5. we propose that VSV treatment combined with the selective regulation of genes such as STAT1 and OASL2 will improve therapeutic outcomes for CUG2-overexpressing tumors PMID: 23306614
6. variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits PMID: 21943158
7. The pronounced difference in gene regulation between the OASL gene agrees with a functional difference between these genes, which must exist as a consequence of the lack of the 2-5A synthetase activity of the OASL protein. PMID: 19203244
8. The expression of OASL and IFIT2 was significantly higher in SLE patients than in controls. PMID: 20506645
9. OASLa, a major isoform of OASL induced in human liver, may mediate anti-HCV activity through two different domains. PMID: 20074559
10. interaction with methyl CpG-binding protein 1 was confirmed in vitro and in vivo and was mapped to the ubiquitin-like domain of p59 OASL PMID: 14728690
11. Proof that OASL is an antiviral protein that works through a novel mechanism distinct from other OASL proteins in other vertebrate species. PMID: 18931074
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亞細胞定位：

[Isoform p56]: Nucleus, nucleolus. Cytoplasm.; [Isoform p30]: Cytoplasm.
蛋白家族：

2-5A synthase family
組織特異性：

Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.
數據庫鏈接：

HGNC: 8090

OMIM: 603281

KEGG: hsa:8638

STRING: 9606.ENSP00000257570

UniGene: Hs.118633

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