Nid1 Antibody, Biotin conjugated
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中文名稱：Nid1兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA015802YD01MO
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Mus musculus (Mouse) Nid1 Polyclonal antibody
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Uniprot No.：
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基因名：Nid1
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別名：Nid1 antibody; Ent antibody; Nidogen-1 antibody; NID-1 antibody; Entactin antibody
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宿主：Rabbit
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反應種屬：Mouse
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免疫原：Recombinant Mouse Nidogen-1 protein (428-665AA)
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免疫原種屬：Mus musculus (Mouse)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.
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基因功能參考文獻：
- Analysis of nidogen-1 and laminin-gamma1 interaction reveals multiple binding modes. PMID: 25387007
- The C-terminal domains of mouse laminin gamma 1 and nidogen 1 mediate interactions complex formation. PMID: 23948589
- nidogen-1 is essential to provide an anti-angiogenic environment of differentiated vessels. PMID: 24280453
- finding demonstrates that nidogens, although homologous proteins, exert their effect on BM assembly through different binding domains, which may in turn result in alterations of BM structure and functions PMID: 22623588
- show that loss of nidogen 2, but not of nidogen 1, promotes lung metastasis of melanoma cells. Histological and ultrastructural analysis of nidogen 1- and 2-deficient lungs did not reveal differences in morphology and ultrastructure of basement membrane PMID: 22260998
- Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain. PMID: 21084308
- This study demonstrates that nidogen-1 is essential for maintenance of normal hippocampal excitability and synaptic plasticity. PMID: 19530222
- Results suggest a non-structural role for nidogen 1 in wound repair. PMID: 19766719
- Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development. PMID: 12015298
- These findings revealed extensive coregulation of nidogen-1 and -2 expression and much more complementary functions of the two nidogens than previously recognized. PMID: 12243745
- Three- to sevenfold increase in nidogen-2 was observed in heart and muscle of mice with nidogen-1 deficiency. Nidogen-2 compensation hypothesis to explain limited phenotype observed following elimination of nidogen-1 gene. PMID: 12475645
- structure of the interacting domains reveals a six-bladed Tyr-Trp-Thr-Asp (YWTD) beta-propeller domain in nidogen bound to laminin epidermal-growth-factor-like (LE) modules III3-5 in laminin (LE3-5) PMID: 12931195
- Expression may promote formation of sinusoids after partial hepatectomy. PMID: 15777791
- Laminin gamma3 chain, located in murine basement membranes, binds to nidogen PMID: 15824114
- Nid1 is essential for late stages of lung development and for maintenance and/or integrity of cardiac tissue PMID: 16024816
- nidogen-2 is equivalent to nidogen-1 in skin-organotypic coculture, and both can promote the development of a functional basement membrane zone PMID: 17008882
- nidogen-1 and -2 have roles in development of the ectodermal basement membrane of the limb bud PMID: 17023412
- expression of the entactin-1 dramatically declined in myogenesis PMID: 17177854
- The lack of nidogen-1, nidogen-2, or both nidogens, plays no crucial role in the occurrence and localization of laminin-111, collagen type IV, and perlecan in murine tubular renal basement membranes. PMID: 17616934
- In capillaries, basement membrane formation is severely impaired in the absence of nidogen-1 and -2, showing an irregular, patchy distribution and a dramatically reduced deposition of collagen IV, perlecan, and particularly laminin-411. PMID: 18356808
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亞細胞定位：Secreted, extracellular space, extracellular matrix, basement membrane.
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數據庫鏈接：
