NXNL1 Antibody

說明書

中文名稱：

NXNL1兔多克隆抗體
貨號：

CSB-PA842649DSR2HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA842649DSR2HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NXNL1 Polyclonal antibody
Uniprot No.：

Q96CM4
基因名：

NXNL1
別名：

NXNL1 antibody; TXNL6 antibody; Nucleoredoxin-like protein 1 antibody; Thioredoxin-like protein 6 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Nucleoredoxin-like protein 1 protein (1-200AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays an important role in retinal cone photoreceptor survival. In association with glucose transporter SLC16A1/GLUT1 and BSG, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors. May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods.
基因功能參考文獻：
1. Study shows that RdCVF acts through binding to Basigin-1 (BSG1), a transmembrane protein expressed specifically by photoreceptors. BSG1 binds to the glucose transporter GLUT1, resulting in increased glucose entry into cones. PMID: 25957687
2. Data suggest a critical role for TXNL6 in MsrA repair of essential lens proteins under oxidative stress conditions and that TXNL6 is important for MsrA defense protection against cataract. PMID: 21079812
3. regulation of the Nucleoredoxin-like genes involves a CRX responsive element that can act as both as a positive regulator of promoter activity and as a modulator of cell-type specificity PMID: 20949100
4. CHX10 regulates RdCVF promoter activity in the inner retina. PMID: 19843539
5. is a truncated thioredoxin-like protein specifically expressed by photoreceptors. The identification of this protein offers new treatment possibilities for retinitis pigmentosa PMID: 15220920
6. RdCVF variants have roles in leber congenital amaurosis PMID: 17249548
7. TXNL6 probably protects retinal cells from photooxidative damage-induced apoptosis via upregulation of NF-kappaB activity PMID: 18474255
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亞細胞定位：

Cell projection, cilium, photoreceptor outer segment.
蛋白家族：

Nucleoredoxin family
數據庫鏈接：

HGNC: 25179

OMIM: 608791

KEGG: hsa:115861

STRING: 9606.ENSP00000305631

UniGene: Hs.661836

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