NTMT1 Antibody

中文名稱：

NTMT1兔多克隆抗體
貨號：

CSB-PA880111HA01HU
規(guī)格：

￥440
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NTMT1 Polyclonal antibody
Uniprot No.：

Q9BV86
基因名：

NTMT1
別名：

AD 003 antibody; Alpha N-terminal protein methyltransferase 1A antibody; C9orf32 antibody; Chromosome 9 open reading frame 32 antibody; Methyltransferase like 11A antibody; Methyltransferase-like protein 11A antibody; Mettl11a antibody; N-terminal RCC1 methyltransferase antibody; NRMT antibody; NTM1A antibody; NTM1A_HUMAN antibody; NTMT1 antibody; X-Pro-Lys N-terminal protein methyltransferase 1A antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human N-terminal Xaa-Pro-Lys N-methyltransferase 1 protein (1-223AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，NTMT1 Antibody (CSB-PA880111HA01HU)，的標記方式是Non-conjugated。對于NTMT1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA880111HB01HU	NTMT1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA880111HC01HU	NTMT1 Antibody, FITC conjugated
Biotin	CSB-PA880111HD01HU	NTMT1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
基因功能參考文獻：
1. CENP-A undergoes alpha-amino trimethylation by the enzyme NRMT in vivo. PMID: 28266506
2. NRMT1 mutants N209I (endometrial cancer) and P211S (lung cancer) alter its catalytic activity and decrease N-terminal trimethylation. PMID: 28556566
3. These studies position the NRMT1 knockout mouse as a useful new system for studying the effects of genomic instability and defective DNA damage repair on organismal and tissue-specific aging. PMID: 25843235
4. NRMT1 adopts a core methyltransferase fold that resembles DOT1L and PRMT but not SET domain family histone methyltransferases. PMID: 26543159
5. kinetic mechanism of NTMT1 PMID: 25771539
6. Concurrent expression of NRMT1 and NRMT2 accelerates the production of trimethylation, and we propose that NRMT2 activates NRMT1 by priming its substrates for trimethylation. PMID: 24090352
7. Peptide methylation assays and substrate immunoprecipitations demonstrate that the canonical M-X-P-K methylation motif is not the only one recognized by NRMT. PMID: 22769851
8. discovery of the first alpha-N-methyltransferase, which we named N-terminal RCC1 methyltransferase (NRMT). PMID: 20668449
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亞細胞定位：

Nucleus. Note=Predominantly nuclear (PubMed:24090352).
蛋白家族：

Methyltransferase superfamily, NTM1 family
數據庫鏈接：

HGNC: 23373

OMIM: 613560

KEGG: hsa:28989

STRING: 9606.ENSP00000361558

UniGene: Hs.744027

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