NSUN3 Antibody, FITC conjugated
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中文名稱：NSUN3兔多克隆抗體, FITC偶聯
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貨號：CSB-PA867156LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) NSUN3 Polyclonal antibody
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Uniprot No.：
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基因名：NSUN3
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別名：6720484A09Rik antibody; AU022521 antibody; FLJ22109 antibody; FLJ22609 antibody; MST077 antibody; MSTP077 antibody; NOL1/NOP2/Sun domain family 3 antibody; NOL1/NOP2/Sun domain family member 3 antibody; NOP2/Sun domain family member 3 antibody; NSUN3 antibody; NSUN3_HUMAN antibody; OTTMUSP00000028633 antibody; Putative methyltransferase NSUN3 antibody; UG0651E06 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial protein (1-200AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position. mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation.
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基因功能參考文獻：
- The authors show that the RNA methyltransferase NSUN3 localises to mitochondria and interacts with mt-tRNA(M)(et) to methylate cytosine 34 (C34) at the wobble position. PMID: 27497299
- The NSUN3-knockout cells showed strong reduction in mitochondrial protein synthesis and reduced oxygen consumption, leading to deficient mitochondrial activity. It reconstituted formation of 5-methylcytidine (m(5)C) at position 34 (m(5)C34) on mt-tRNA(Met) with recombinant NSUN3 in the presence of AdoMet, demonstrating that NSUN3-mediated m(5)C34 formation initiates f(5)C34 biogenesis. PMID: 27214402
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相關疾病：Mitochondrial complex deficiency (PubMed:27356879). A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected (PubMed:27356879). Clinical features include combined developmental disability, microcephaly, failure to thrive, recurrent increased lactate levels in plasma, muscular weakness, proximal accentuated, external ophthalmoplegia and convergence nystagmus (PubMed:27356879). Defects are probably caused by deficient methylation and formylation of mt-tRNA(Met) wobble cytosine (PubMed:27356879). The disease may be caused by mutations affecting the gene represented in this entry.
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亞細胞定位：Mitochondrion matrix.
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蛋白家族：Class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family
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數據庫鏈接：
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