NR5A2 Antibody, Biotin conjugated

說明書

中文名稱：

NR5A2兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA016066LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NR5A2 Polyclonal antibody
Uniprot No.：

O00482
基因名：

NR5A2
別名：

Alpha-1-fetoprotein transcription factor antibody; B1-binding factor antibody; B1F antibody; B1F2 antibody; CPF antibody; CYP7A promoter-binding factor antibody; FTF antibody; FTZ F1 antibody; FTZ F1beta antibody; FTZ-F1 antibody; FTZ-F1beta antibody; hB1F 2 antibody; hB1F antibody; hB1F-2 antibody; Hepatocytic transcription factor antibody; Liver receptor homolog 1 antibody; LRH-1 antibody; LRH1 antibody; Nr5a2 antibody; NR5A2_HUMAN antibody; Nuclear receptor subfamily 5 group A member 2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Nuclear receptor subfamily 5 group A member 2 protein (182-291AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38.
基因功能參考文獻：
1. Lrh-1 transcriptionally regulates Oat2. PMID: 29669824
2. Rev-erbalpha regulates Cyp7a1 and cholesterol metabolism through its repression of the Lrh-1 receptor. PMID: 29237721
3. transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas; findings support the notion that, in the pancreas, the transcriptional networks involved in differentiation-specific functions also suppress inflammatory programs; under conditions of genetic or environmental constraint, these networks can be subverted to foster inflammation PMID: 29443959
4. our data indicated that miR-381 inhibited migration and invasion of non-small cell lung cancer (NSCLC)by targeting LRH-1, and may represent a novel potential therapeutic target and prognostic marker for NSCLC. PMID: 29048619
5. NR5A2-mediated cancer cell survival is facilitated through augmentation of GATA6 and anti-apoptotic factor BCL-XL levels. PMID: 27586588
6. the expression level of LRH-1 can be used as a marker in the early diagnosis of unexplained recurrent spontaneous abortion. PMID: 28531169
7. Liver receptor homologue1 (LRH1) is a direct target of miR30d in colorectal carcinoma cells. PMID: 28440426
8. Results show that LRH-1 is a direct target gene of miR-374b and that decreased miR-374b expression may contribute to the promotion of LRH-1-mediated tumorigenesis of colon cancer. PMID: 29128635
9. NR5A2 may be important in the pathophysiology of preterm birth and exploring noncoding regulators of NR5A2 is warranted PMID: 26761123
10. Our study suggests that miR-219-5p regulated the proliferation, migration, and invasion of human gastric cancer cells by suppressing LRH-1. PMID: 27983934
11. Liver receptor homolog-1 was identified as a direct target gene of miR-136 PMID: 28710032
12. miR-27b-3p levels were found to be significantly negatively correlated with both NR5A2 and CREB1 levels in breast cancer tissues. PMID: 27809310
13. The fusion transcript NR5A2-KLHL29FT was identified in normal and cancerous colonic epithelia. It is due to an uncharacterized polymorphic germline insertion of the NR5A2 sequence from chromosome 1 into the KLHL29 locus at chromosome 2, rather than a chromosomal rearrangement. NR5A2-KLH29FT expression levels were significantly lower in colon cancers than in matched normal colonic epithelia. PMID: 28081303
14. Additionally, the authors solved the structure of the human LRH-1 DNA-binding domain bound to a DR0 motif located within the Oct4 promoter. PMID: 27984042
15. miR-376c inhibits non-small-cell lung cancer cell growth and invasion by targeting LRH-1 PMID: 27049310
16. The first crystal structure of the LRH-1-PGC1alpha complex , which depicts hydrophobic contacts is identified and described. PMID: 28363985
17. The dramatic repositioning is influenced by a differential ability to establish stable face-to-face pi-pi-stacking with the LRH-1 residue His-390, as well as by a novel polar interaction mediated by the RJW100 hydroxyl group. The differing binding modes result in distinct mechanisms of action for the two agonists. PMID: 27694446
18. The role of NR5A2 in regulating pancreatic cancer stem cell properties and epithelial-mesenchymal transition of pancreatic carcinoma cells PMID: 27996162
19. demonstrate aberrant expressions of SF-1 and LRH-1 in endometriotic granulosa-lutein cells PMID: 26530052
20. Down-regulation of MicroRNA-381 promotes cell proliferation and invasion in colon cancer cells through up-regulation of LRH-1. PMID: 26320367
21. The present study indicates that miR-381 may be a novel tumor suppressor that blocks HCC growth and invasion by targeting LRH-1. PMID: 26677080
22. The SNPs rs3790843 and rs3790844 in the NR5A2 gene are associated with pancreatic cancer risk in Japanese subjects. PMID: 26592175
23. SERBP1 is a component of the LRH-1 transcriptional complex. PMID: 26398198
24. These findings demonstrate that in vitro LRH-1 can act like SF-1 and compensate for its deficiency. PMID: 25896302
25. These findings show that POD-1/TCF21 regulates SF-1 and LRH-1 by distinct mechanisms, contributing to the understanding of POD-1 involvement and its mechanisms of action in adrenal and liver tumorigenesis. PMID: 26421305
26. Studies indicate that liver receptor homolog-1 (LRH-1) is critical involvement in multiple types of cancer, and represents a desirable target for therapeutic applications. PMID: 25951367
27. in spermatozoa the LRH-1 effects are closely integrated with the estrogen signaling, supporting LRH-1 as a downstream effector of the estradiol pathway on some sperm functions. PMID: 26241668
28. LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner. PMID: 26400164
29. Data suggest LRH1/NR5A2 exhibits phospholipid-mediated allosteric control of protein-protein binding interface in interactions with TIF2 (co-activator; transcription intermediary factor 2) and SHP (co-repressor; small heterodimer partner protein). PMID: 26553876
30. Results identify LRH-1 as a critical component of the anti-inflammatory and fungicidal response of alternatively activated macrophages that acts upstream from the IL-13-induced 15-HETE/PPARgamma axis. PMID: 25873311
31. AFPR may play a pivotal role in HBV-related hepatocarcinogenesis. PMID: 25943101
32. our findings present supportive evidence that ApoM is a regulator of human LRH-1 transcription, and further reveal the importance of ApoM as a critical regulator of bile acids metabolism PMID: 25987835
33. these data demonstrate that copper-mediated nuclear receptor dysfunction disrupts liver function in WD and potentially in other disorders associated with increased hepatic copper levels. PMID: 26241054
34. Analysis of breast cancer samples reveals that a high LRH-1 level is inversely correlated with CDKN1A expression in breast cancer patients and is associated with poor prognosis PMID: 25435372
35. loss of LRH-1 by siRNA or miR-451 mimics significantly impaired Wnt/beta-catenin activity, leading to G0/G1 cell cycle arrest PMID: 25869073
36. the NR5A2 rs3790844 polymorphism is associated with increased OS of GC patients in the dominant model, and similar results were found among the female group and tumor size >5 cm group for NR5A2 rs3790843 polymorphism. PMID: 25514243
37. This study demonstrates a critical proproliferative role for LRH-1 in established colon cancer cell lines. PMID: 25675535
38. during chronic colitis, TNF suppresses intestinal steroidogenic gene expression by inhibiting the activity of NR5A2, thus decreasing glucocorticoid synthesis and sustaining chronic inflammation. PMID: 24570488
39. LRH1 overexpression is associated with increased pancreatic cancer growth and metastatic spread PMID: 24769073
40. Data (including data from transgenic overexpression/gene silencing) suggest that NR5A2 modulates signal transduction/cell proliferation in mammary cells; mammary morphology exhibits significant reduction in lateral budding after NR5A2 overexpression. PMID: 24564400
41. report the genome-wide location and molecular function of LRH-1 in breast cancer cells and reveal its therapeutic potential for the treatment of breast cancers, notably for tumors resistant to treatments currently used in therapies. PMID: 24520076
42. Data conclude that SF-1 regulates aromatase expression in GCT; over-expression of LRH-1 suggests that this receptor may be involved in the pathogenesis of GCT by mechanisms other than the regulation of aromatase. PMID: 23537609
43. Lrh-1 is necessary for maintenance of the corpus luteum, for promotion of decidualization and for formation of the placenta. PMID: 23817023
44. Data indicate that sequence divergence has differentially impacted ligand binding and protein dynamics in NR5A2. PMID: 23737522
45. Experimental evaluation of the predicted ligands identified two compounds that inhibit the transcriptional activity of LRH-1 and diminish the expression of the receptor's target genes. PMID: 23667258
46. Expression of human LRH-1 is regulated in a tissue-specific manner, and that the novel promoter region is controlled by the Sp-family, NR5A-family and PGC-1alpha in ovarian granulosa cells in a coordinated fashion. PMID: 23471216
47. this study indicates that LRH-1 acts as a transcriptional activator in the regulation of OCT4 gene expression through the cooperative interaction with three binding sites directly or/and indirectly. PMID: 23000165
48. HNF4alpha and LRH-1 promote active transcription histone marks on the Cyp7a1 promoter that are reversed by FGF19 in a SHP-dependent manner PMID: 23038264
49. The lipid-free receptor undergoes previously unrecognized structural fluctuations, allowing it to interact with widely expressed co-repressors. PMID: 22504882
50. Data show that single nucleotide polymorphisms (SNPs) in ABO, sonic hedgehog (SHH), telomerase reverse transcriptase (TERT), nuclear receptor subfamily 5, group A, member 2 (NR5A2) were found to be associated with pancreatic cancer risk. PMID: 22125638
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亞細胞定位：

Nucleus.
蛋白家族：

Nuclear hormone receptor family, NR5 subfamily
組織特異性：

Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells.
數據庫鏈接：

HGNC: 7984

OMIM: 604453

KEGG: hsa:2494

STRING: 9606.ENSP00000356331

UniGene: Hs.33446

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