NPC2 Antibody, FITC conjugated

^{Rare Species}

說明書

產品詳情

產品名稱：

Rabbit anti-Dog NPC2 Polyclonal antibody
Uniprot No.：

Q28895
基因名：

NPC2
別名：

NPC2 antibody; NPC intracellular cholesterol transporter 2 antibody; Epididymal secretory protein E1 antibody; cE1 antibody; Niemann Pick type C2 protein homolog antibody
宿主：

Rabbit
反應種屬：

Dog
免疫原：

Recombinant Dog NPC intracellular cholesterol transporter 2 protein (22-149AA)
免疫原種屬：

Dog
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.
亞細胞定位：

Secreted. Endoplasmic reticulum. Lysosome.
蛋白家族：

NPC2 family
組織特異性：

Epididymis. High levels are found in the caput and corpus regions. Weaker levels in the distal cauda and in the efferent ducts.
數據庫鏈接：

STRING: 9615.ENSCAFP00000024889

UniGene: Cfa.3781

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