NLRP4 Antibody
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中文名稱：NLRP4兔多克隆抗體
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貨號(hào)：CSB-PA123062
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規(guī)格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA123062(NLRP4 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA123062(NLRP4 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：NLRP4
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別名：Cancer/testis antigen 58 antibody; CLR19.5 antibody; CT58 antibody; FLJ32126 antibody; NACHT, leucine rich repeat and PYD containing 4 antibody; NACHT, LRR and PYD containing protein 4 antibody; NACHT, LRR and PYD domains-containing protein 4 antibody; NALP4_HUMAN antibody; NLR family, pyrin domain containing 4 antibody; NLRP4 antibody; Nucleotide binding oligomerization domain, leucine rich repeat and pyrin domain containing 4 antibody; PAAD and NACHT containing protein 2 antibody; PAAD and NACHT-containing protein 2 antibody; PAN2 antibody; PYPAF4 antibody; PYRIN and NACHT-containing protein 2 antibody; PYRIN containing APAF1 like protein 4 antibody; PYRIN-containing APAF1-like protein 4 antibody; Ribonuclease inhibitor 2 antibody; RNH2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthetic peptide of Human NLRP4
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:50-1:200 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情
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功能：May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.
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基因功能參考文獻(xiàn)：
- NLRP4 is an important mediator of cardiac remodeling in vitro and in vivo. PMID: 28486191
- This study describes conformational stability of native NLRP14 and mutants in their monomeric and dimeric states and compares them to NLRP4, a representative of a native pyrin domain fold. PMID: 25403012
- Structural and functional analysis of the NLRP4 pyrin domain. PMID: 22928810
- Our results provide molecular insight into the mechanisms by which NLRP4-DTX4 targets TBK1 for degradation. PMID: 22388039
- NLRP4 is recruited to and accumulates in bacteria-containing phagosomes and transiently dissociates from beclin1 following group A streptococcus infection, thereby controlling the autophagic flux crucial for cell-autonomous antibacterial resistance. PMID: 21209283
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蛋白家族：NLRP family
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數(shù)據(jù)庫鏈接：
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