NKIRAS1 Antibody

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NKIRAS1 Polyclonal antibody
Uniprot No.：

Q9NYS0
基因名：

NKIRAS1
別名：

2400004O09Rik antibody; I kappa B interacting Ras like protein 1 antibody; I-kappa-B-interacting Ras-like protein 1 antibody; Kappa B Ras 1 antibody; Kappa B Ras protein 1 antibody; Kappa B-Ras protein 1 antibody; KappaB Ras1 antibody; KappaB-Ras1 antibody; KBRAS 1 antibody; KBRAS1 antibody; KBRS1_HUMAN antibody; NF kappa B inhibitor interacting Ras like protein 1 antibody; NF-kappa-B inhibitor-interacting Ras-like protein 1 antibody; NFKB inhibitor interacting Ras like 1 antibody; NFKB inhibitor interacting Ras like protein 1 antibody; NKIRAS 1 antibody; nkiras1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human NF-kappa-B inhibitor-interacting Ras-like protein 1 protein (1-192AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，NKIRAS1 Antibody (CSB-PA885767LA01HU)，的標記方式是Non-conjugated。對于NKIRAS1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA885767LB01HU	NKIRAS1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA885767LC01HU	NKIRAS1 Antibody, FITC conjugated
Biotin	CSB-PA885767LD01HU	NKIRAS1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
基因功能參考文獻：
1. It was demonstrated that elevated levels of mRNA for NKIRAS1 was significantly associated both with loss of methylation in NKIRAS1 CpG-islands and methylation in a number of miRNA genes. PMID: 25869366
2. Significant correlation was found between alterations of methylation status of miR-34b/c, miR-193a and the expression level of NKIRAS1 target gene in the primary lung tumors. PMID: 23156677
3. Low kappaB-Ras1 expression is associated with gliomas. PMID: 21302000
4. It was shown the decreased expression level of NKIRAS1 in Renal cell carcinoma PMID: 20693965
亞細胞定位：

Cytoplasm.
蛋白家族：

Small GTPase superfamily, Ras family, KappaB-Ras subfamily
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 17899

OMIM: 604496

KEGG: hsa:28512

STRING: 9606.ENSP00000373411

UniGene: Hs.173202

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