NKD1 Antibody
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中文名稱：NKD1兔多克隆抗體
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貨號：CSB-PA853369LA01HU
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規(guī)格：￥440
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圖片：
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Western Blot
Positive WB detected in: Rat heart tissue
All lanes: NKD1 antibody at 1.8μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 53 kDa
Observed band size: 53 kDa -
Immunofluorescence staining of HepG2 cells with CSB-PA853369LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) NKD1 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：NKD1 antibody; NKD antibody; PP7246 antibody; Protein naked cuticle homolog 1 antibody; Naked-1 antibody; hNkd antibody; hNkd1 antibody
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宿主：Rabbit
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反應種屬：Human, Rat
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免疫原：Recombinant Human Protein naked cuticle homolog 1 protein (269-384AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產(chǎn)品，NKD1 Antibody (CSB-PA853369LA01HU)，的標記方式是Non-conjugated。對于NKD1 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應用范圍：ELISA, WB, IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關產(chǎn)品
靶點詳情
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功能：Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.
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基因功能參考文獻：
- the downregulation of NKD1 may be involved in the proliferation and migration of osteosarcoma cells through the activation of the canonical Wnt signaling pathway. PMID: 29115501
- The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocellular carcinoma cells. PMID: 27231134
- HNF1A-AS1 promoted HCC cell proliferation by repressing the NKD1 and p21 expression. PMID: 28292020
- Data indicate that microRNA miR-744 activated Wnt/beta-catenin pathway by targeting multiple negative regulators of Wnt/beta-catenin signaling, including SFRP1, GSK3beta, TLE3 and NKD1, and that NKD1 is a major functional target of miR-744. PMID: 28107193
- NKD1 showed significantly increased level after induction chemotherapy achieved complete remission in follow-up paired acute myeloid leukemia patients ( p < 0.001). These findings indicated that reduced NKD1 expression is associated with unfavorable clinical outcome in cytogenetically normal acute myeloid leukemia. PMID: 28443469
- Low NKD1 expression is associated with hepatocellular carcinoma. PMID: 27507614
- Silencing of NKD1 significantly inhibited the proliferation and invasion of osteosarcoma cells. PMID: 28032380
- Suggest that NKD1 plays an important role in invasion in human breast cancer and it appears to be a potential prognostic marker for patients with breast cancer. PMID: 26097589
- Reduced NKD1 protein expression correlates with a poor prognosis in NSCLC PMID: 21599923
- Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling PMID: 19956716
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亞細胞定位：Cell membrane. Cytoplasm.
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蛋白家族：NKD family
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組織特異性：Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen.
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數(shù)據(jù)庫鏈接：
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