NEK11 Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

Q8NG66
基因名：

NEK11
別名：

4932416N14Rik antibody; FLJ23495 antibody; NEK11 antibody; NEK11_HUMAN antibody; NEK11S/L antibody; Never in mitosis A-related kinase 11 antibody; NIMA (never in mitosis gene a) related kinase 11 antibody; NIMA (never in mitosis gene a)- related kinase 11 antibody; NIMA related kinase 11L antibody; NIMA related kinase 11S antibody; NIMA-related kinase 11 antibody; NimA-related protein kinase 11 antibody; Serine/threonine-protein kinase Nek11 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human NEK11
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
基因功能參考文獻：
1. contributes to response of colorectal cancer cells to genotoxic agents and is essential for survival either with or without exposure to DNA damage PMID: 26501353
2. Results show that downregulation of NEK11 in drug resistant cells might contribute to drug resistance in ovarian cancer. PMID: 24969318
3. NEK11 controls degradation of CDC25A by directly phosphorylating CDC25A on residues whose phosphorylation is required for beta-TrCP mediated CDC25A polyubiquitylation and degradation. PMID: 20090422
4. Nek11 has a role in the S-phase checkpoint downstream of the caffeine-sensitive pathway PMID: 12154088
5. Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells PMID: 15161910
6. NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. PMID: 19734889
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亞細胞定位：

Nucleus. Nucleus, nucleolus.
蛋白家族：

Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
組織特異性：

Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.
數(shù)據(jù)庫鏈接：

HGNC: 18593

OMIM: 609779

KEGG: hsa:79858

STRING: 9606.ENSP00000372857

UniGene: Hs.657336

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