NEBL Antibody

中文名稱：

NEBL兔多克隆抗體
貨號：

CSB-PA015673LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of PC-3 cells with CSB-PA015673LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NEBL Polyclonal antibody
Uniprot No.：

O76041
基因名：

NEBL
別名：

NEBL antibody; LNEBLNebulette antibody; Actin-binding Z-disk protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Nebulette protein (438-533AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，NEBL Antibody (CSB-PA015673LA01HU)，的標記方式是Non-conjugated。對于NEBL Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA015673LB01HU	NEBL Antibody, HRP conjugated	ELISA
FITC	CSB-PA015673LC01HU	NEBL Antibody, FITC conjugated
Biotin	CSB-PA015673LD01HU	NEBL Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. Isoform 2 might play a role in the assembly of focal adhesion.
基因功能參考文獻：
1. Survival analysis suggested that overexpressed NEBL in patients with colorectal cancer was associated with a positive prognosis for overall survival. PMID: 29257257
2. LASP2 may play a significant role in suppressing CRC progression and provided a novel biomarker for CRC therapy PMID: 28606091
3. The levels of phosphorylated FAK (Tyr397 and Tyr925) were increased after overexpressing Lasp2 and were downregulated by transfecting Lasp2-siRNA. PMID: 28667800
4. predisposition to multibacillary leprosy in Vietnam is associated with CUBN and NEBL common variants in the chromosome 10p13 linkage region PMID: 24563210
5. We identify the SH3 domains of nebulin and nebulette as novel ligands of proline-rich regions of Xin and XIRP2 PMID: 23985323
6. Data indicate that lasp-2 interacts with the focal adhesion proteins vinculin and paxillin. PMID: 23389630
7. Report oncogenic potential of MLL-NEBL and NEBL-MLL fusion genes in acute myeloid leukemia. PMID: 23340173
8. Different mutations in nebulette transgene trigger a pathological cascade leading to endocardial fibroelastosis and dilated cardiomyopathy in mutant embryonic mouse hearts. PMID: 20951326
9. our data demonstrate the importance of this cardiac-specific nebulin isoform in myofibril organization and function. Our data demonstrate that nebulette plays a significant role in the structure and stability of the cardiac Z-line. PMID: 11822876
10. LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions PMID: 15004028
11. filamin-C, a known component of striated muscle Z-lines, interacts with nebulette modules PMID: 17987659
12. the importance of the nebulette-TPM interactions in the maintenance and stability of the thin filaments. PMID: 18823973
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亞細胞定位：

[Isoform 2]: Cytoplasm.
組織特異性：

Abundantly expressed in cardiac muscle, but not in skeletal or smooth muscle. Localized to Z-lines in cardiac cells and to dense bodies in nonmuscle cells. Isoform 2 is expressed in non-muscle cells such as in fibroblasts.
數據庫鏈接：

HGNC: 16932

OMIM: 605491

KEGG: hsa:10529

STRING: 9606.ENSP00000366326

UniGene: Hs.5025

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