NCOA5 Antibody, FITC conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NCOA5 Polyclonal antibody
Uniprot No.：

Q9HCD5
基因名：

NCOA5
別名：

NCOA5 antibody; KIAA1637 antibody; Nuclear receptor coactivator 5 antibody; NCoA-5 antibody; Coactivator independent of AF-2 antibody; CIA antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Nuclear receptor coactivator 5 protein (112-283AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).
基因功能參考文獻：
1. knockout of NCOA5 can suppress the epithelial - mesenchymal transition (EMT) in hepatocellular carcinoma cells. PMID: 29626478
2. This study provides new insights and evidences that NOCA5 over-expression was significantly correlated with progression and prognosis in luminal breast cancer. However, the precise cellular mechanisms for NOCA5 in luminal breast cancer need to be further explored. PMID: 27847318
3. NCOA5 low expression correlates with survival in esophageal squamous cell carcinoma. PMID: 25416054
4. suggest that NCOA5 is a haploinsufficient tumor suppressor and that NCOA5 deficiency increases susceptibility to both glucose intolerance and HCC, partially by increasing IL-6 expression PMID: 24332041
5. gene polymorphism confers susceptibility to psoriasis in a Southern European population PMID: 21645569
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亞細胞定位：

Nucleus.
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 15909

KEGG: hsa:57727

STRING: 9606.ENSP00000290231

UniGene: Hs.654991

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