N4BP1 Antibody

說明書

中文名稱：

N4BP1兔多克隆抗體
貨號：

CSB-PA620222
規(guī)格：

￥2024
圖片：
Western blot analysis of extracts from MCF-7 cells, 293 cells and Jurkat cells, using N4BP1 antibody.
其他：

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) N4BP1 Polyclonal antibody
Uniprot No.：

O75113
基因名：

N4BP1
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Synthesized peptide derived from internal of Human N4BP1.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines. Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity. Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates.
基因功能參考文獻(xiàn)：
1. The p34 interacts with the WW1 domain of NEDD4-1, an interaction that enhances NEDD4-1 stability. PMID: 24141722
亞細(xì)胞定位：

Cytoplasm, cytosol. Nucleus. Nucleus, nucleolus. Nucleus, PML body.
蛋白家族：

N4BP1 family
組織特異性：

Detected in heart, lung, brain, liver, skeletal muscle, pancreas, kidney, spleen, testis and ovary.
數(shù)據(jù)庫鏈接：

HGNC: 29850

KEGG: hsa:9683

STRING: 9606.ENSP00000262384

UniGene: Hs.511839

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