Mut Antibody, HRP conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Mus musculus (Mouse) Mut Polyclonal antibody
Uniprot No.：

P16332
基因名：

Mut
別名：

Mmut antibody; Mut antibody; Methylmalonyl-CoA mutase antibody; mitochondrial antibody; MCM antibody; EC 5.4.99.2 antibody; Methylmalonyl-CoA isomerase antibody
宿主：

Rabbit
反應種屬：

Mouse
免疫原：

Recombinant Mouse Methylmalonyl-CoA mutase, mitochondrial protein (31-748AA)
免疫原種屬：

Mus musculus (Mouse)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.
基因功能參考文獻：
1. On a high protein diet, mutant mice display disease exacerbation, including elevated blood ammonia, and catastrophic weight loss, which, in Mut(ki/ki) mice, is rescued by hydroxocobalamin treatment. This study expands knowledge of MMAuria, introduces the discovery of new biomarkers, and constitutes the first in vivo proof of principle of cobalamin treatment in mut-type MMAuria. PMID: 27519416
2. The mouse methylmalonic aciduria- related genes, Mmaa, Mmab, and Mut may have specialized functions depending on the tissue or cell type. PMID: 23022071
3. Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~61%. PMID: 19372376
4. methylmalonyl-CoA mutase has a role in methylmalonic aciduria and early neonatal lethality PMID: 14555645
5. Mitochondrial dysfunction in Mut is reported. PMID: 19088183
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亞細胞定位：

Mitochondrion matrix. Mitochondrion. Cytoplasm.
蛋白家族：

Methylmalonyl-CoA mutase family
數據庫鏈接：

KEGG: mmu:17850

STRING: 10090.ENSMUSP00000130941

UniGene: Mm.259884

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