MYOG Antibody, FITC conjugated
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中文名稱：MYOG兔多克隆抗體, FITC偶聯
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貨號：CSB-PA015360LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) MYOG Polyclonal antibody
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Uniprot No.：
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基因名：MYOG
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別名：bHLHc3 antibody; cb553 antibody; Class C basic helix-loop-helix protein 3 antibody; MYF 4 antibody; Myf-4 antibody; MYF4 antibody; MYOG antibody; MYOG_HUMAN antibody; Myogenic factor 4 antibody; Myogenic factor 4 myogenin antibody; Myogenin antibody; Myogenin myogenin factor 4 antibody; OTTHUMP00000039094 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Myogenin protein (1-224AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts.
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基因功能參考文獻：
- Findings indicate a interplay between A-kinase anchoring protein 6 (AKAP6) and myogenin. PMID: 26563778
- results indicate that myogenin is a positive regulator in transcriptional regulation of MEGF10 in skeletal muscle PMID: 25044114
- Sustained GSK3beta activity represses a critical regulatory step in the myogenic cascade, contributing to the undifferentiated, proliferative phenotype in alveolar rhabdomyosarcoma. PMID: 24577092
- Our study illustrates that focal myogenin immunoreactivity occurs uncommonly in fibroepithelial polyps of the lower female genital tract. PMID: 23944986
- Data indicate that muscle MYOG mRNA expression doubled, whereas MSTN protein expression decreased following immobilization. PMID: 24215591
- the FACT complex promotes myogenin-dependent transcription PMID: 23364797
- Human muscle samples were analysed at different time-points post-denervation to evaluate changes in myogenin expression and their relationship with skeletal muscle atrophy. PMID: 21672341
- After 2 years of denervation, expression of myogenin protein in myonuclei was decreased, but after 3 years of denervation, no expression of myogenin protein in myonuclei was found in denervated posterior cricoarytenoid muscles. PMID: 19961777
- The physical interaction of CARM1 and PCAF is likely pivotal for the activation of PCAF in the downstream of CARM1 pathway for inducing myogenin under Tetradecanoylphorbol Acetate -induced differentiation. PMID: 20213728
- study showed that a rapid rearrangement of myogenin expression occurs in exercised human skeletal muscles in response to a single bout of exercise PMID: 14997318
- myogenin and myocyte enhancer factor-2 expression are triggered by membrane hyperpolarization during human myoblast differentiation PMID: 15084602
- induction of Id1 not only blocks transcriptional activity but also induces myogenin degradation by blocking formation of myogenin-E47 protein complexes. PMID: 15322112
- there is a functional link between dysferlin and myogenin in the differentiation of skeletal muscle PMID: 16608842
- MYOG is a positive diagnostic for biliary tract rhabdomyosarcoma. PMID: 17378682
- MYOG had positive staining in this melanotic neuroectodermal tumor. PMID: 17378694
- Both PCAF and BRG1 are also involved in the activation of the myogenin gene in rhabdomyosarcoma PMID: 17468105
- transcription of Cugbp1 gene in muscle is regulated by myogenin and E proteins PMID: 17531403
- Diffuse myogenin expression by immunohistochemistry is an independent marker of poor survival in pediatric rhabdomyosarcoma. PMID: 18708938
- PAX3 mRNA is an Staufen 1-mediated mRNA decay target whose decay promotes myogenesis whereas myogenin mRNA is a classical nonsense-mediated mRNA decay target encoding a protein required for myogenesis PMID: 19095803
- Underexpression of myogenin is associated with liver metastases in rhabdomyosarcoma. PMID: 19372547
- Decreased Jun-D and myogenin expression in muscle wasting of human cachexia. PMID: 19470832
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亞細胞定位：Nucleus.
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