MXI1 Antibody, FITC conjugated

說明書

中文名稱：

MXI1兔多克隆抗體, FITC偶聯
貨號：

CSB-PA015254LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MXI1 Polyclonal antibody
Uniprot No.：

P50539
基因名：

MXI1
別名：

bHLHc11 antibody; Class C basic helix-loop-helix protein 11 antibody; MAD 2 antibody; MAD2 antibody; MAX dimerization protein 2 antibody; MAX interacting protein 1 antibody; Max interactor 1 antibody; Max related transcription factor antibody; MAX-interacting protein 1 antibody; MGC43220 antibody; MXD 2 antibody; MXD2 antibody; MXI 1 antibody; MXI antibody; mxi1 antibody; MXI1 protein antibody; MXI1_HUMAN antibody; Protein MXI1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Max-interacting protein 1 protein (75-173AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.
基因功能參考文獻：
1. Reactive oxygen species mediates hypoxia-induced VEGF by upregulation of Mxi1-0. PMID: 28065785
2. results suggest that Mxi1-0 regulates the growth of HUVECs via the IL-8 and ERK1/2 pathways, which apparently reciprocally activate each other PMID: 28575053
3. MYC-HEG and MXI1-LEG levels are associated with poor prognosis in patients with breast cancer, suggesting that they may be useful molecular markers in breast cancer prognosis prediction. PMID: 24685915
4. MicroRNA-155 promotes glioma cell proliferation via the regulation of MXI1. PMID: 24376632
5. MXI1-0 appears to be a downstream target of MYCN-dependent signaling pathways and may contribute to N-Myc-dependent cell growth and proliferation. PMID: 24403858
6. These findings reveal, for the first time, the novel functions of cooperation of miR243p and miR27a3p from two clusters in promoting cell proliferation through MXI1. PMID: 23254855
7. Mxi1 can act as a tumour suppressor in human glioblastomas through a molecular mechanism involving the transcriptional down-regulation of cyclin B1 gene expression. PMID: 11875718
8. These findings support MXI1 as a putative tumor suppressor gene involved in conventional melanoma progression. PMID: 14559981
9. Mxi1-SRalpha is an isoform with enhanced transcriptional repression potential PMID: 15467743
10. Data show that PTEN and MXI1 were two candidate tumor suppressor genes on 10q23 and 10q24-q25 and may be potentially involved in the initiation and progression of prostate carcinoma. PMID: 15476185
11. Mxi-D may play an important role in the c-Myc family protein network acting as a dominant negative isoform of Mxi-F stimulated by c-Myc PMID: 15809730
12. p300 can acetylate DNA-bound Myc:Max complexes and that acetylated Myc:Max heterodimers efficiently interact with Miz-1 PMID: 16126174
13. MXI1 mutation appears to play a role in the pathogenesis of a small subset of cases, and suggests an alternative mechanism to MYC amplification for disruption of the MYC/MAD/MAX network in medulloblastoma. PMID: 17102621
14. These results provide evidence of direct regulation of Mxi1 by FOXO3a and imply an additional mechanism through which the PI3-kinase/Akt/FOXO pathway can modulate Myc function. PMID: 17452451
15. Mad1, Mxi1 and Rox genes were expressed and displayed mutations in haematological malignancies. PMID: 17577784
16. Mxi1 gains functional complexity by encoding isoforms with shared and distinct activities PMID: 17697116
17. Missense mutations in Mad1, Mxi1 and Rox were found in acute leukemia patients. PMID: 18457265
18. Mxi1 is an important downstream target of HIF that contributes to pVHL-deficient renal cancer tumorigenesis PMID: 19018165
19. MAX interactor-1 (MXI1) gene is directly regulated by HIF-1alpha protein in neuroblastoma and breast cancer cells. PMID: 19254710
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相關疾病：

Prostate cancer (PC)
亞細胞定位：

Nucleus.
組織特異性：

High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
數據庫鏈接：

HGNC: 7534

OMIM: 176807

KEGG: hsa:4601

STRING: 9606.ENSP00000331152

UniGene: Hs.602078

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