MXD3 Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MXD3 Polyclonal antibody
Uniprot No.：

Q9BW11
基因名：

MXD3
別名：

bHLHc13 antibody; Class C basic helix-loop-helix protein 13 antibody; FLJ35523 antibody; Likely ortholog of mouse Max dimerization protein 3 antibody; MAD3_HUMAN antibody; MAX dimerization protein 3 antibody; Max dimerizer 3 antibody; Max-associated protein 3 antibody; Max-interacting transcriptional repressor MAD3 antibody; MGC2383 antibody; mxd3 antibody; Myx antibody; OTTHUMP00000223596 antibody; OTTHUMP00000223598 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Max dimerization protein 3 protein (1-206AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.
基因功能參考文獻：
1. results indicate that MXD3 is a potential new target and that the use of MXD3 siRNA nanocomplexes is a novel therapeutic approach for neuroblastoma PMID: 28419087
2. The results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor. PMID: 25554682
3. Acute MXD3 activation results in a transient increase in DAOY cell proliferation while persistent activation of MXD3 results in an overall decrease in cell number, suggesting that the time course of MXD3 expression dictates the cellular outcome. PMID: 25053245
4. Increased level and/or duration of MXD3 expression ultimately reduces cell numbers via increased cell death and cell cycle arrest in medulloblastoma cells. PMID: 22808009
亞細胞定位：

Nucleus.
數據庫鏈接：

HGNC: 14008

OMIM: 609450

KEGG: hsa:83463

STRING: 9606.ENSP00000401867

UniGene: Hs.743332

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