MUC5B Antibody
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中文名稱：MUC5B兔多克隆抗體
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貨號：CSB-PA831664
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規(guī)格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA831664(MUC5B Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：2300002I04Rik antibody; A130042M24 antibody; AV085033 antibody; Cervical mucin antibody; Cervical mucin MUC5B antibody; High molecular weight salivary mucin MG1 antibody; MG1 antibody; MUC-5B antibody; MUC5 antibody; MUC5B antibody; MUC5B_HUMAN antibody; MUC9 antibody; Mucin 5 subtype B, tracheobronchial antibody; Mucin 5B antibody; Mucin 5B oligomeric mucus/gel forming antibody; Mucin-5 subtype B antibody; Mucin-5B antibody; Sublingual gland mucin antibody; tracheobronchial antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthetic peptide of Human MUC5B
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:25-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.
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基因功能參考文獻(xiàn)：
- the combination of intracellular packing of the MUC5B mucin and the submucosal gland morphology creates an efficient machine for producing linear mucin bundles. PMID: 29440393
- resistin induced MUC5AC and MUC5B expression via activation of different signaling pathways in human airway epithelial cells. PMID: 29604272
- Genetic variations in the MUC5B gene can influence dental caries. PMID: 28944591
- The expression of MUC5B mRNA increased with increases in NH concentration, and was significantly higher compared to that in untreated cells. H. pylori may affect the expression of MUC5AC, MUC2, MUC5B, and MUC6 in AGS cells via CagA and/or NH, but not E-cadherin. PMID: 29869461
- MUC5B was identified as PRP-1 receptor in human chondrosarcoma JJ012 cell line using Ligand-receptor capture technology. PMID: 29138803
- The MUC5B promoter polymorphism is strongly associated with interstitial lung abnormalities and specific radiologic subtypes of ILA, with varying degrees of heterogeneity in the underlying populations PMID: 28893869
- The associations between MUC5B rs35705950 and short telomere length with extent of fibrosis, histopathological features of usual interstitial pneumonia, and reduced survival in patients with chronic hypersensitivity pneumonitis suggest shared pathobiology with IPF, and might help to stratify risk. PMID: 28648751
- High-Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells PMID: 29286856
- IL-33 induced MUC5AC mRNA and MUC5AC protein, and also goblet cell hyperplasia at air liquid interface culture in human nasal epithelial cells. In addition to that, IL-33 induced MUC5B and FOXA3, and reduces FOXJmRNA. PMID: 27776277
- MUC5B has physiologic functions in the mucus gel that ensure normal mucus clearance. PMID: 27845589
- Down-regulation of MUC5B profoundly alters proliferation, migration and invasion of gastrointestinal cancer cells. PMID: 28972071
- Mucins and AQP5 gene expression were significantly higher in patients with OME relative to controls. A 2-fold increase in MUC5B correlated with increased hearing loss (air-bone gap: 7.45 dB [95% CI, 2.65-12.24 dB]; sound field: 6.66 dB [95% CI, 6.63-6.69 dB]), effusion viscosity (2.75 mL/mg; 95% CI, 0.89-4.62 mL/mg), middle ear epithelial thickness (3.5 mum; 95% CI, 1.96-5.13 mum), and neutrophil infiltration (odds rat... PMID: 28594978
- This study identified rare and common variants in the MUC5B gene that are associated with type 2 diabetes in Han Chinese. These findings suggest that dysregulated MUC5B expression may be involved in the pathogenesis of type 2 diabetes. PMID: 28346466
- a critical regulatory domain that contains the MUC5B promoter variant and has a highly conserved forkhead box protein A2 (FOXA2) binding motif, is identified. PMID: 28272906
- There is no evidence of major proteolytic processing of D-domains during the production of the mature secreted polymeric mucin in normal and cystic fibrosis primary bronchial epithelial cells. PMID: 26993521
- Different rs35705950 SNP alleles are associated with different CT imaging phenotypes of pulmonary fibrosis. PMID: 26836909
- MUC5B was significantly more often detected in middle ear effusion fluid relative to MUC5AC. MUC5B presence was statistically associated with mucoid effusions relative to serous effusions. PMID: 27729120
- Results collectively indicate unique links between dual-specificity phosphatase 28 (DUSP28) and mucins MUC5B/MUC16 and their roles in pancreatic cancer. PMID: 27230679
- Study provides evidence showing that MUC5B expression in cancer cells contributes to certain tumorigenic properties of breast cancer cells, such as cell growth, adhesion, clonogenic ability and drug chemo-resistance. PMID: 26984395
- this study shows that histamine activated the NF-kappaB pathway, contributing to MUC5B overproduction and secretion in nasal epithelial cells PMID: 26574733
- This study showed that MUC5B minor allele predisposes to poradic idiopathic pulmonary fi brosis (spIPF), familial interstitial pneumonia (FIP) and idiopathic non-speci fi c interstitial pneumonia. In spIPF, survival is not in fl uenced by MUC5B alleles. In FIP, MUC5B minor allele predicts better survival. PMID: 26699835
- MUC5B may play a role in the development of pediatric fibrotic lung disease in patients with Surfactant Protein C mutations PMID: 25858779
- the MUC5B polymorphism rs35705950 is associated with increased risk of idiopathic pulmonary fibrosis susceptibility, severity, and the decreased overall survival. PMID: 26823827
- The MUC5B promoter polymorphism is the strongest and the most replicated genetic risk factor for Idiopathic pulmonary fibrosis. It is involved in disease pathogenesis through an increase in MUC5B expression in terminal bronchi and honeycombed cysts. PMID: 26595739
- We propose a mechanism whereby MUC5B decreases surface tension lowering capacity of alveolar surfactant at areas with maximal mechanical stress PMID: 26539479
- These results suggest that MUC5B production can be regulated by ECM components and that MUC5B is upregulated by fibronectin and laminin via the integrin, ERK, and NF-kappaB dependent pathway. PMID: 26057585
- MUC5B promoter genotype was not associated with high attenuation areas on lung computed tomography. PMID: 26514822
- Overexpression of MUC5B has been described in idiopathic pulmonary fibrosis lungs. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201507-1322LE#.V2WAGNLrtNs PMID: 26871672
- The variant allele of a common MUC5B promoter variant, rs35705950, is significantly associated with both familial and sporadic idiopathic pulmonary fibrosis. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201509-1872LE#.V2WBpNLrtNs PMID: 26871673
- Mucin 5B promoter polymorphism is associated with the risk for interstitial lung diseases mainly in older male Chinese subjects PMID: 25121989
- MUC5B is a novel prognostic biomarker for patients with non-small cell lung cancer (NSCLC)carrying EGFR mutations but not for patients with NSCLC carrying wild-type EGFR PMID: 26224019
- MUC5B has recently been shown to be associated with idiopathic pulmonary fibrosis susceptibility and survival. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201505-1010OC#.VwqiYdLrvyA PMID: 26331942
- strong association between the MUC5B promoter rs35705950 minor T allele and idiopathic pulmonary fibrosis susceptibility particularly evident in the Caucasian population, milder but still significant in the Asian population [meta-analysis] PMID: 26512610
- this is the first study to successfully validate the association between rs35705950 and IPF in a Japanese ethnicity. PMID: 25581455
- Increased expression of MUC5B was associated with bacterial biofilm formation in chronic rhinosinusitis patients. PMID: 25638393
- MUC5B polymorphism confers susceptibility to idiopathic pulmonary fibrosis in Europeans and Asians--{review} PMID: 25926289
- Both compounds down regulated mucin 5 subtype B, and peptidoglycan recognition protein 1 in vaginal tissue PMID: 25333937
- the combination of MUC5B and TTF-1 expression is useful for discriminating adenocarcinomas from squamous cell carcinomas, yielding prognostic significance in patients with lung adenocarcinoma. PMID: 25733373
- An increase of MUC5B abundance found in the sinus secretions of pediatric patients with chronic rhinosinusitis. PMID: 25420179
- The T allele at rs35705950 of the MUC5B gene is associated with usual interstitial pneumonitis PMID: 25317858
- The expression of a subset of mucins (MUC2, MUC6, MUC5B) was also correlated with sialyl-Tn expression in LS174T cells. PMID: 24840470
- These results show for the first time that Staphylococcus enterotoxin A induces MUC5B expression via TLR2, ERK1/2, and p38 MAPK signaling pathway in human airway epithelial cells. PMID: 24717875
- The MUC5B rs2672794 CC genotype was associated with a significantly increased risk of coal workers' pneumoconiosis, compared with the TT genotype. PMID: 24924948
- Adolescents with very high intensity of dental caries disease had increased levels of MUC1 and MUC5B. PMID: 24441930
- Sputum is not inert and degradation reduces apparent mucin concentrations and sputum elasticity. PMID: 24332705
- These results suggest that visfatin induces MUC8 and MUC5B expression through p38 MAPK/ROS/NF-kappaB signaling pathway in human airway epithelial cells. PMID: 24885580
- TSLP induces MUC5B expression via the ERK1/2 and p38 MAPK signaling pathway in human airway epithelial cells. PMID: 24792379
- we report the expression pattern of MUC2, MUC5AC, MUC5B, and MUC6 in a large series of colorectal carcinomas PMID: 23807779
- This study suggests that although both MUC5B and TERT polymorphisms confer independent risks for interstitial lung disease (ILD), MUC5B rs35705950 may, in particular, contribute differentially to idiopathic pulmonary fibrosis and other ILD entities. PMID: 24434656
- One SNP in the MUC5B gene having association with chronic otitis media with effusion in study population. PMID: 23929584
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相關(guān)疾病：Pulmonary fibrosis, idiopathic (IPF)
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亞細(xì)胞定位：Secreted.
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組織特異性：Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands of airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall bladder, and pancreas.
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